HER3/ERBB3 Protein, Human, Recombinant

Name: HER3/ERBB3 Protein, Human, Recombinant
Brand: TargetMol
SKU: TMPY-00399
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: p85-sErbB3, p45-sErbB3, p180-ErbB3, MDA-BF-1, LCCS2, HER3, erbB3-S, ErbB-3, erb-b2 receptor tyrosine kinase 3, EEBB3, c-erbB-3, c-erbB3) Copy Product Info

Synonyms: p85-sErbB3, p45-sErbB3, p180-ErbB3, MDA-BF-1, LCCS2, HER3, erbB3-S, ErbB-3, erb-b2 receptor tyrosine kinase 3, EEBB3, c-erbB-3, c-erbB3

Catalog No. TMPY-00399 Copy Product Info

HER3/ERBB3 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 69.3 kDa and the accession number is P21860-1.

Pack Size	Price	USA Stock	Global Stock
5 µg	$44	-	In Stock
10 µg	$68	-	In Stock
20 µg	$108	-	In Stock
50 µg	$198	-	In Stock
100 µg	$347	-	In Stock
200 µg	$583	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:92.6%

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Immobilized Recombinant Human HER3/ErbB3 Protein (Cat#TMPY-00399) at 2 μg/mL (100 μL/well) can bind Anti-Human Her3 Antibody, Human IgG1, the EC50 is 3-12 ng/mL (QC tested).
Description	HER3/ERBB3 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 69.3 kDa and the accession number is P21860-1.
Species	Human
Expression System	HEK293 Cells
Tag	Tag Free
Accession Number	P21860-1
Construction	A DNA sequence encoding the human ERBB3 (NP_001973.2) (Met1-Thr643) was expressed with five amino acids (DDDDK) at the C-terminus. Predicted N terminal: Ser 20
Protein Purity	> 85 % as determined by SDS-PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
Synonyms	p85-sErbB3, p45-sErbB3, p180-ErbB3, MDA-BF-1, LCCS2, HER3, erbB3-S, ErbB-3, erb-b2 receptor tyrosine kinase 3, EEBB3, c-erbB-3, c-erbB3
Research Background	ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

Chemical Properties

Molecular Weight

69.3 kDa (predicted)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.