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Visomitin

Catalog No. T4168 CAS 934826-68-3

Synonyms: SKQ1

Visomitin (SKQ1) is a mitochondria-targeted antioxidant that decreases transmembrane potential and production of reactive oxygen species (ROS).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Visomitin, CAS 934826-68-3

Pack Size	Availability	Price/USD
5 mg	In stock	$ 43.00
10 mg	In stock	$ 68.00
25 mg	In stock	$ 126.00
50 mg	In stock	$ 207.00
100 mg	In stock	$ 365.00
1 mL * 10 mM (in DMSO)	In stock	$ 59.00

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Purity: 98%

Purity: 97.08%

Purity: 95.44%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Visomitin (SKQ1) is a mitochondria-targeted antioxidant that decreases transmembrane potential and production of reactive oxygen species (ROS).
In vitro	Direct treatment of tumor inﬁltrating leukocytes with Visomitin (SkQ1) does not inﬂuence their cytotoxicity against Panc02 cells. Visomitin reduces heavily the proliferation of human PDAC cells at 500 nM concentration while not affecting the viability of the cell lines.
In vivo	In a study on pancreatic ductal adenocarcinoma (PDAC)-bearing mice, continuous treatment with Visomitin (SkQ1) was found to modify systemic angiogenic factors. Specifically, this treatment led to a decrease in serum KC levels and an increase in VEGF molecules, indicating altered angiogenesis. Additionally, Visomitin treatment resulted in reduced levels of MIP1a and prolactin, alongside elevated amounts of IL-6 and IL-13. The pretreatment setting showed a decrease in TGF-b levels. Contrarily, Visomitin treatment across all protocols reduced the percentage of NKT cells. Although the median survival of PDAC-bearing mice was prolonged with Visomitin treatment, the survival increase did not achieve statistical significance.
Cell Research	Panc02 cells are treated 48 h with different concentrations of Visomitin (SkQ1). Cell viability after Visomitin treatment is measured with an EZ4U Kit as described by the manufacturers. Brie?y, 20,000 cells per well are seeded in 96-wellplates and let grow overnight. Afterwards, cells are treated without the medium exchange. A substrate compound from the kit is added and the cells are further incubated for 5 hr at 37°C to convert the yellow colored tetrazolium to its red formazan derivate by living cells. The absorbance is measured at 450 nm
Animal Research	Female C57BL/6 mice are used in this study. For experiments on both acute and chronic pancreatitis, mice are divided in three groups. Group A (acute pancreatitis (AP) n=8; chronic pancreatitis (CP) n=12) is treated with 5?nmol/kg Visomitin (SkQ1), group B (AP n=8; CP n=12) is the untreated control, and group C (AP n=8; CP n=7) is the sham group, which is injected intraperitoneally with 0.9% NaCl instead of cerulein and is therefore the negative control group without pancreatitis. For experiments on acute pancreatitis, mice are pretreated with Visomitin for 8 weeks prior to induction of pancreatitis. Mice designated for experiments on chronic pancreatitis receive Visomitin at the same concentration for 8 weeks in parallel with induction of pancreatitis

Synonyms	SKQ1
Molecular Weight	617.61
Formula	C36H42BrO2P
CAS No.	934826-68-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (89.05 mM)

References and Literature

1. Samuilov VD, et al. Effect of Cationic Plastoquinone SkQ1 on Electron Transfer Reactions in Chloroplasts and Mitochondria from Pea Seedlings. Biochemistry (Mosc). 2015 Apr;80(4):417-23 2. Iomdina EN, et al. Mitochondria-targeted antioxidant SkQ1 reverses glaucomatous lesions in rabbits. Front Biosci (Landmark Ed). 2015 Jan 1;20:892-901 3. Manskikh VN, et al. Effect of the mitochondria-targeted antioxidant SkQ1 on development of spontaneous tumors in BALB/c mice. Biochemistry (Mosc). 2014 Oct;79(10):1136-9.

Citations

1. Wang X H, Song T Z, Zheng H Y, et al. Jejunal epithelial barrier disruption triggered by reactive oxygen species in early SIV infected rhesus macaques. Free Radical Biology and Medicine. 2021 2. Li Y H, Wang X H, Huang W W, et al.Severe fever with thrombocytopenia syndrome virus induces platelet activation and apoptosis via a reactive oxygen species-dependent pathway.Redox Biology.2023: 102837. 3. Dong W, Wang G, Bai Y, et al.Repurposing an Antioxidant to Kill Mycobacterium tuberculosis by Targeting the 50S Subunit of the Ribosome.Biomolecules.2023, 13(12): 1793.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Oxidation-Reduction Compound Library Anti-Fibrosis Compound Library FDA-Approved & Pharmacopeia Drug Library Anti-Liver Cancer Compound Library Approved Drug Library Anti-Ovarian Cancer Compound Library

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Keywords

Visomitin 934826-68-3 Immunology/Inflammation Metabolism NF-Κb Reactive Oxygen Species inhibit Inhibitor SKQ 1 SKQ1 SKQ-1 inhibitor

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