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DNA Damage/DNA Repair DNA/RNA Synthesis Psoralen

Psoralen

Catalog No. T2942   CAS 66-97-7
Synonyms: Furocoumarin, Ficusin, psoralene

Psoralen is a furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division.

Psoralen, CAS 66-97-7
Pack Size Availability Price/USD Quantity
10 mg In stock 59.00
25 mg In stock 107.00
50 mg In stock 186.00
100 mg In stock 335.00
200 mg In stock 469.00
1 mL * 10 mM (in DMSO) In stock 59.00
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Purity 99.34%
Purity 100.00%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Psoralen is a furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division.
Targets&IC50 Others
In vivo Psoralen has been characterized as a tumor suppressor in various tumors[1]. Psoralen ameliorates sex hormone deficiency-induced osteoporosis in female and male mice. It has antiosteoporosis effect in ovariectomy-induced osteoporotic rats via stimulating osteoblastic differentiation from bone mesenchymal stem cells[2].
Cell Research
The effects of psoralen on cell proliferation are measured by MTT assay. MCF-10A and MCF-7/ADR cells are cultured in 96-well plates at a cell density of 2×104 cells per well for 48 h. The medium is then removed and replaced by fresh medium containing different concentrations of psoralen (0, 21.5, 43.0, 64.5, 86.0, 107.5 μM) for 48 h. Cells in the negative control group are incubated with RPMI-1640 culture medium supplemented with 0.1% dimethyl sulfoxide (DMSO). Cells are incubated with 10 µL MTT (5 mg/mL) for 4 h, and then discarded the medium and added 200 µL DMSO. The spectrophotometric absorbance is measured at 490 nm with enzyme-labeling instrument after the crystals were fully dissolved. (Only for Reference)
Cell lines: Human breast cancer MCF-7/ADR cells, MCF-10A, and MCF-7 cells
Synonyms Furocoumarin , Ficusin , psoralene
Purity 99.34%
Molecular Weight 186.17
Formula C11H6O3
CAS No. 66-97-7

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 35 mg/mL (188 mM)

Ethanol: <1 mg/mL

Water: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Wang X, et al. Biol Pharm Bull. 2016, 39(5):815-22. 2. Xiaomei Yuan, et al. BioMed Research International. 2016, 2016:6869452.

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Natural Compound Library for HTS Anti-cancer Compound Library Clinical Compound Library Anti-infection Compound Library Apoptosis Compound Library Immunology/Inflammation Compound Library Selected Plant-sourced Compound Library DNA Damage & Repair Compound Library Anti-cancer Approved drug Library Anti-cancer Clinical Compound Library Anti-aging Compound Library Antitumor Natural Products Library Natural Compoud Library in Chinese Pharmacopoeia Anti-cancer Drug library Drug Repurposing Library FDA Approved & Pharmacopeial Drug Library Traditional Chinese Medicine Monomer Library Anti-Breast Cancer Compound Library

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