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Tyrosine Kinase/Adaptors PKA Piceatannol

Piceatannol

Catalog No. T0610   CAS 10083-24-6
Synonyms: trans-Piceatannol, Astringenin

Piceatannol is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activation and gene expression of TNF-induced. It is synthetic from the conversion of resveratrol by cytochrome P450 1B1.

Piceatannol, CAS 10083-24-6
Pack Size Availability Price/USD Quantity
5 mg In stock 50.00
10 mg In stock 68.00
25 mg In stock 130.00
50 mg In stock 189.00
100 mg In stock 267.00
200 mg In stock 480.00
1 mL * 10 mM (in DMSO) In stock 50.00
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Purity 98.66%
Purity 98.00%
Purity 99.39%
Biological Description
Chemical Properties
Storage & Solubility Information
Preparing Solutions
Description Piceatannol is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activation and gene expression of TNF-induced. It is synthetic from the conversion of resveratrol by cytochrome P450 1B1.
Targets&IC50 cAK ,   MLCK ,   PKC
Kinase Assay In Vitro Protein-tyrosine Kinase Assays: Recombinant Syk is expressed in baculovirus-infected St9 cells. Assays of recombinant Syk activity are carried out using angiotensin I peptide as substrate. The enzyme activities of recombinant Syk are measured by phosphorylation of angiotensin I peptide in the presence of various concentrations of Piceatannol.
Cell Research
Cells are exposed to increasing concentrations of Piceatannol. For the determination of cell proliferation, cells are assayed at 72 hours by trypan blue exclusion using a hemocytometer. After 1 week, colonies are stained with 1.25% crystal violet and quantified by measuring the absorbance at 595 nm. (Only for Reference)
Cell lines: LNCaP, DU145, and PC-3
Synonyms trans-Piceatannol , Astringenin
Purity 98.66%
Molecular Weight 244.24
Formula C14H12O4
CAS No. 10083-24-6

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 24.4 mg/mL (100 mM)

Ethanol: 24.4 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Solution 1

1% DMSO+30% polyethylene glycol+1% Tween 80: 30 mg/mL

Citations

References and Literature
1. Oliver JM, et al. J Biol Chem, 1994, 269(47), 29697-29703. 2. Wang BH, et al. Planta Med, 1998, 64(3), 195-199. 3. Su L, et al. J Biol Chem, 2000, 275(17), 12661-12666. 4. Wieder T, et al. Leukemia, 2001, 15(11), 1735-1742. 5. Ashikawa K, et al. J Immunol, 2002, 169(11), 6490-6497.

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Natural Compound Library for HTS Anti-cancer Compound Library Apoptosis Compound Library Autophagy Compound Library Neuronal Signaling Compound Library Tyrosine kinase inhibitor library Immunology/Inflammation Compound Library Selected Plant-sourced Compound Library Kinase Inhibitor Library GPCR Compound Library Anti-cancer Approved drug Library Polyphenolic Natural Compound Library Anti-aging Compound Library Hematonosis Compound Library Antitumor Natural Products Library Natural Compoud Library in Chinese Pharmacopoeia Anti-cancer Active Compound library Anti-cancer Drug library Drug Repurposing Library Anti-Inflammatory Tradition Chinese Medicine Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Drug-induced Liver Injury (DILI) Compound Library Tibetan medicine Compound Library FDA Approved & Pharmacopeial Drug Library Traditional Chinese Medicine Monomer Library Cytoskeletal Signaling Pathway Compound Library Anti-fibrosis Compound Library

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