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O6-Benzylguanine

Catalog No. T7539 CAS 19916-73-5

O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine <a href="/target/DNA" style="display: inline; color: #c13a36">DNA</a> alkyltransferase (AGT) inactivator.

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O6-Benzylguanine, CAS 19916-73-5

Pack Size	Availability	Price/USD
25 mg	In stock	$ 43.00
50 mg	In stock	$ 62.00
100 mg	In stock	$ 99.00
1 mL * 10 mM (in DMSO)	In stock	$ 30.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.

Molecular Weight	241.254
Formula	C12H11N5O
CAS No.	19916-73-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 48mg/mL(198.96mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Tacastacas J D , Chan D V , Carlson S . Evaluation of O6-Benzylguanine−Potentiated Topical Carmustine for Mycosis FungoidesA Phase 1-2 Clinical Trial[J]. JAMA Dermatology, 2017, 153(5):págs. 413-420. 2. Dolan M E , Pegg A E . O6-Benzylguanine and its role in chemotherapy[J]. Clinical Cancer Research, 1997, 3(6):837-847.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Anti-Cancer Drug Library Apoptosis Compound Library Drug Repurposing Compound Library Anti-Aging Compound Library Clinical Compound Library Pediatric Drug Library Hematonosis Compound Library DNA Damage & Repair Compound Library Anti-Liver Cancer Compound Library

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Keywords

O6-Benzylguanine 19916-73-5 Apoptosis Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA Alkylation DNA/RNA Synthesis pancreatic transcriptional PARP1 p53 inhibit cyclin O-6-Benzylguanine antineoplastic cancer O6Benzylguanine O6 Benzylguanine guanine Inhibitor p21 analog inhibitor

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