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Nitrosoglutathione

Nitrosoglutathione
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Purity:99.68%
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Nitrosoglutathione

Catalog No. T19930Cas No. 57564-91-7
Nitrosoglutathione (GSNO) is an endogenous transnitrosation donor involved in S-nitrosation of a variety of cellular proteins. GSNO, an exogenous NO donor and substrate of rat alcohol dehydrogenase class III isoenzyme, inhibits cerebral angiotensin II-dependent and -independent AT1 receptor responses.
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Pack SizePrice/USDAvailabilityQuantity
5 mg$48In Stock
10 mg$67In Stock
25 mg$107In Stock
50 mg$156In Stock
100 mg$229In Stock
500 mg$572In Stock
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Related Compound Libraries of "Nitrosoglutathione"

Product Introduction

Bioactivity
Description
Nitrosoglutathione (GSNO) is an endogenous transnitrosation donor involved in S-nitrosation of a variety of cellular proteins. GSNO, an exogenous NO donor and substrate of rat alcohol dehydrogenase class III isoenzyme, inhibits cerebral angiotensin II-dependent and -independent AT1 receptor responses.
In vitro
GSNO completely abolished the AngII-dependent AT1 receptor-mediated vasoconstriction of cerebral arteries. GSNO had no impact on responses to other vasoconstrictors sharing (phenylephrine, U46619) or not (5-HT) the same signalling pathway[1].
In vivo
Elevated blood pressure, proteinuria, and intrauterine growth restriction associated with PE were induced in Sprague-Dawley rats using L-NAME. These were partially reversed with the use of GSNO[3].
AliasS-Nitrosoglutathione, SNOG, Glutathione thionitrite, GSNO
Chemical Properties
Molecular Weight336.32
FormulaC10H16N4O7S
Cas No.57564-91-7
Storage & Solubility Information
Storagestore at low temperature,keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: Soluble
H2O: 20 mg/ml(59.47 mM)
Solution Preparation Table
H2O
1mg5mg10mg50mg
100 mM0.0297 mL0.1487 mL0.2973 mL1.4867 mL

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