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Nitrosoglutathione

Catalog No. T19930 CAS 57564-91-7

Synonyms: S-Nitrosoglutathione, SNOG, GSNO, Glutathione thionitrite

GSNO is an endogenous transnitrosation donor involved in S-nitrosation of a variety of cellular proteins. GSNO, an exogenous NO donor and substrate of rat alcohol <a href="/target/Dehydrogenase" style="display: inline; color: #c13a36">Dehydrogenase</a> class III isoenzyme, inhibits cerebral angiotensin II-dependent and -independent AT1 receptor responses.

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Nitrosoglutathione, CAS 57564-91-7

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5 mg	In stock	$ 59.00

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Purity: 99.68%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	GSNO is an endogenous transnitrosation donor involved in S-nitrosation of a variety of cellular proteins. GSNO, an exogenous NO donor and substrate of rat alcohol dehydrogenase class III isoenzyme, inhibits cerebral angiotensin II-dependent and -independent AT1 receptor responses.
In vitro	GSNO completely abolished the AngII-dependent AT1 receptor-mediated vasoconstriction of cerebral arteries. GSNO had no impact on responses to other vasoconstrictors sharing (phenylephrine, U46619) or not (5-HT) the same signalling pathway[1].
In vivo	Elevated blood pressure, proteinuria, and intrauterine growth restriction associated with PE were induced in Sprague-Dawley rats using L-NAME. These were partially reversed with the use of GSNO[3].

Synonyms	S-Nitrosoglutathione, SNOG, GSNO, Glutathione thionitrite
Molecular Weight	336.31
Formula	C10H16N4O7S
CAS No.	57564-91-7

Storage

store at low temperture

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: Soluble

H2O: 20 mg/ml(59.47 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Marie-Lynda Bouressam, et al. S-nitrosoglutathione inhibits cerebrovascular angiotensin II-dependent and -independent AT 1 receptor responses: A possible role of S-nitrosation. Br J Pharmacol. 2019 Jun;176(12):2049-2062. 2. Eva Nozik-Grayck, et al. Pulmonary vasoconstriction by serotonin is inhibited by S-nitrosoglutathione. Am J Physiol Lung Cell Mol Physiol. 2002 May;282(5):L1057-65. 3. Caneta Brown, et al. The effects of S-nitrosoglutathione and S-nitroso-N-acetyl-D, L-penicillamine in a rat model of pre-eclampsia. J Nat Sci Biol Med. 2013 Jul;4(2):330-5. 4. D E Jensen, et al. S-Nitrosoglutathione is a substrate for rat alcohol dehydrogenase class III isoenzyme. Biochem J. 1998 Apr 15;331 ( Pt 2)(Pt 2):659-68.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Endocrinology-Hormone Compound Library Human Metabolite Library Human Endogenous Metabolite Library Bioactive Compounds Library Max ReFRAME Related Library Immunology/Inflammation Compound Library

Related Products

Related compounds with same targets

Camellianin A Ramiprilat [Sar1, Ile8]-Angiotensin II Azilsartan Methyl Ester Angiotensin II (3-8), human BIBS 39 Aliskiren D6 hemifumarate Pratosartan

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Keywords

Nitrosoglutathione 57564-91-7 Endocrinology/Hormones Immunology/Inflammation RAAS NO Synthase I/R RVC 588 S-Nitrosoglutathione inhibit SNOG GSNO antioxidant Inhibitor RVC-588 Angiotensin Receptor injury Glutathione thionitrite superoxide ischemia RVC588 inhibitor

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