store at low temperture
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
GSNO is an endogenous transnitrosation donor involved in S-nitrosation of a variety of cellular proteins. GSNO, an exogenous NO donor and substrate of rat alcohol <a href="/target/Dehydrogenase" style="display: inline; color: #c13a36">Dehydrogenase</a> class III isoenzyme, inhibits cerebral angiotensin II-dependent and -independent AT1 receptor responses.
Pack Size | Availability | Price/USD | Quantity |
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5 mg | In stock | $ 59.00 |
Description | GSNO is an endogenous transnitrosation donor involved in S-nitrosation of a variety of cellular proteins. GSNO, an exogenous NO donor and substrate of rat alcohol dehydrogenase class III isoenzyme, inhibits cerebral angiotensin II-dependent and -independent AT1 receptor responses. |
In vitro | GSNO completely abolished the AngII-dependent AT1 receptor-mediated vasoconstriction of cerebral arteries. GSNO had no impact on responses to other vasoconstrictors sharing (phenylephrine, U46619) or not (5-HT) the same signalling pathway[1]. |
In vivo | Elevated blood pressure, proteinuria, and intrauterine growth restriction associated with PE were induced in Sprague-Dawley rats using L-NAME. These were partially reversed with the use of GSNO[3]. |
Synonyms | S-Nitrosoglutathione, SNOG, GSNO, Glutathione thionitrite |
Molecular Weight | 336.31 |
Formula | C10H16N4O7S |
CAS No. | 57564-91-7 |
store at low temperture
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: Soluble
H2O: 20 mg/ml(59.47 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Nitrosoglutathione 57564-91-7 Endocrinology/Hormones Immunology/Inflammation RAAS NO Synthase I/R RVC 588 S-Nitrosoglutathione inhibit SNOG GSNO antioxidant Inhibitor RVC-588 Angiotensin Receptor injury Glutathione thionitrite superoxide ischemia RVC588 inhibitor