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Nexopamil

Catalog No. T28164 CAS 136033-49-3

Synonyms: LU49938, LU 49938, LU-49938

Nexopamil (LU-49938) is a calcium channel antagonist and a 5-hydroxytryptamine 2A receptor antagonist. Nexopamil inhibits 5-HT-induced contraction and proliferation of mesenchymal cells.

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Nexopamil, CAS 136033-49-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 120.00
5 mg	In stock	$ 290.00
10 mg	In stock	$ 440.00
25 mg	In stock	$ 728.00
50 mg	In stock	$ 987.00
100 mg	In stock	$ 1,390.00
500 mg	In stock	$ 2,770.00

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Purity: 100%

ee: 100%

Purity: 99.74%

ee: 98.54%

Purity: 99.43%

ee: 100%

Purity: 99.39%

ee: 97.32%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Nexopamil (LU-49938) is a calcium channel antagonist and a 5-hydroxytryptamine 2A receptor antagonist. Nexopamil inhibits 5-HT-induced contraction and proliferation of mesenchymal cells.
In vitro	Nexopamil abolished in a concentration-dependent way the serotonin-induced [3H]thymidine incorporation into DNA, and the serotonin-induced increase in a number of cells. Nexopamil partially blocked the serotonin-induced mesangial cell contraction, in a dose-dependent manner blocking 5-HT2 receptors and the voltage-operated Ca2+ channels.[3]

Synonyms	LU49938, LU 49938, LU-49938
Molecular Weight	404.59
Formula	C24H40N2O3
CAS No.	136033-49-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (135.94 mM)

References and Literature

1. Hohlfeld T, et al. Protection of reperfused ischemic pig myocardium by nexopamil, a new combined Ca2+ and serotonin antagonist. J Cardiovasc Pharmacol. 1994 ; 23(6):922-931. 2. Nearing BD, et al. Potent antifibrillatory effect of combined blockade of calcium channels and 5-HT2 receptors with nexopamil during myocardial ischemia and reperfusion in dogs: comparison to diltiazem. J Cardiovasc Pharmacol. 1996 ; 27(6):777-787. 3. Park SJ, et al. The combined 5-HT2 receptor and calcium channel inhibitor LU49938 restores endothelium dependent responses in the regenerated endothelium of the porcine coronary artery. Cardiovasc Res. 1995 ; 29(1):95-101. 4. Montero A, et al. The effect of LU-49938 (nexopamil) on the activation by serotonin of mesangial cells. Fundam Clin Pharmacol. 1995 ; 9(2):175-180. 5. Park SJ, et al. Effects of the combined 5-hydroxytryptamine2 receptor and Ca2+ channel antagonist LU49938 on the responsiveness of isolated porcine coronary arteries with and without endothelium. J Cardiovasc Pharmacol. 1994 ; 24(3):517-522. 6. Kirchengast M, et al. Inhibition by the combined Ca2+ and 5-HT2 receptor antagonist nexopamil (LU 49938) of intracoronary thrombus formation in a canine model of arterial stenosis and intimal damage. J Cardiovasc Pharmacol. 1993 ; 22(5):687-694.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library GPCR Compound Library Neuronal Signaling Compound Library Bioactive Compound Library Neurotransmitter Receptor Compound Library Bioactive Compounds Library Max

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Keywords

Nexopamil 136033-49-3 GPCR/G Protein Membrane transporter/Ion channel Metabolism Neuroscience Calcium Channel 5-HT Receptor LU49938 LU 49938 LU-49938 inhibitor inhibit

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