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NADH disodium salt

Name: NADH disodium salt
Brand: TargetMol
SKU: T5283
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: NADH, disodium salt hydrate, Disodium NADH) Copy Product Info

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Synonyms: NADH, disodium salt hydrate, Disodium NADH

Catalog No. T5283 Copy Product Info

Purity: 99.85%

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NADH disodium salt hydrate belongs to natural products and is a coenzyme of oxidoreductases with oral activity, serving as an electron donor in processes such as glycolysis, the tricarboxylic acid cycle, and β-oxidation. This compound is widely used in metabolism-related experimental research.

Cas No. 606-68-8

Pack Size	Price	USA Stock	Global Stock
500 mg	$45	In Stock	In Stock
1 g	$56	In Stock	In Stock
5 g	$118	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.85%

Color:White to Yellow

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	NADH disodium salt hydrate belongs to natural products and is a coenzyme of oxidoreductases with oral activity, serving as an electron donor in processes such as glycolysis, the tricarboxylic acid cycle, and β-oxidation. This compound is widely used in metabolism-related experimental research.
In vitro	Methods: In an ethanol system, different concentrations of NADH (0–40 μM) were mixed with DPPH solution, incubated at room temperature for 30 minutes, and absorbance at 517 nm was measured. Results: NADH exhibited concentration-dependent DPPH radical scavenging activity, but with lower potency than gallic acid. [1] Methods: Different concentrations of NADH (0–50 mM) were mixed with Pdots, incubated at room temperature, and fluorescence spectra were measured. Results: Pdots showed high sensitivity and selectivity for NADH. [2] Methods: NADH disodium salt (2 mM) was mixed with R848-N3 (1 mM) and TBR (2 mM), sonicated (1.0 MHz, 2.5 W/cm², 5 min), and analyzed by HPLC. Results: NADH disodium salt successfully mediated the reduction of R848-N3 to R848, confirming its in vitro activity as an electron donor. [3]
In vivo	Methods: NADH disodium salt (5 μMol/mouse, single dose) was administered to mice by intraperitoneal injection, and urine was collected to detect the excretion of nicotinamide and its metabolites. Results: NADH disodium salt increased urinary excretion of nicotinamide and its metabolites in mice. [4] Methods: Ethanol-loaded mice were given NADH disodium salt (500 mg/kg, single dose) by gavage to observe alcohol metabolism and liver injury indicators. NADH disodium salt (1000 mg/kg, single dose) was administered to male C57BL/6J mice by intraperitoneal injection, and tissue NAD+ levels were measured. Results: NADH disodium salt promoted alcohol metabolism and prevented and ameliorated early liver injury induced by acute alcohol exposure; NADH disodium salt enhanced tissue NAD+ levels in mice. [5]
Synonyms	NADH, disodium salt hydrate, Disodium NADH

Chemical Properties

Molecular Weight	709.4
Formula	C₂₁H₂₇N₇Na₂O₁₄P₂
Cas No.	606-68-8
Smiles	[Na+].[Na+].NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Relative Density.	1.955 g/cm3 at 20℃

Storage & Solubility Information

Storage

Store under nitrogen,Store at low temperature,Keep away from direct sunlight,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (140.96 mM), Sonication is recommended.

H2O: 250 mg/mL (352.41 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (4.65 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.4096 mL	7.0482 mL	14.0964 mL	70.4821 mL
5 mM	0.2819 mL	1.4096 mL	2.8193 mL	14.0964 mL
10 mM	0.1410 mL	0.7048 mL	1.4096 mL	7.0482 mL
20 mM	0.0705 mL	0.3524 mL	0.7048 mL	3.5241 mL
50 mM	0.0282 mL	0.1410 mL	0.2819 mL	1.4096 mL
100 mM	0.0141 mL	0.0705 mL	0.1410 mL	0.7048 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

β-oxidationTCAreduced coenzymeorally activeNADH, disodium HydrateNADH disodium saltNADH disodiumNADHInhibitorinhibitglycolysisEndogenousMetaboliteEndogenous Metabolite

Related Tags: NADH disodium salt chemical structure | NADH disodium salt in vivo | NADH disodium salt in vitro | NADH disodium salt formula | NADH disodium salt molecular weight