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VU0467154

Name: VU0467154
Brand: TargetMol
SKU: T17244
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17244Cas No. 1451993-15-9

VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor (M4 mAChR).

VU0467154

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Purity: 99.53%

Catalog No. T17244Cas No. 1451993-15-9

VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor (M4 mAChR).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$42	In Stock	In Stock
2 mg	$60	In Stock	In Stock
5 mg	$98	In Stock	In Stock
10 mg	$135	In Stock	In Stock
25 mg	$263	In Stock	In Stock
50 mg	$445	In Stock	In Stock
100 mg	$773	In Stock	In Stock
200 mg	$1,050	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$108	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.53%

Appearance:Solid

Color:White to Orange

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor (M4 mAChR).
Targets&IC50	M4 mAChR:6.2(pEC50,human), M4 mAChR:6(pEC50,Cynomolgus monkey), M4 mAChR:7.75(pEC50, rat)
In vitro	VU0467154 potentiates the response to ACh with pEC50s of 7.75(rat), 6.2(human) and 6(cynomolgus monkey) for M4 receptor, respectively. VU0467154 does not potentiate the ACh response at rat and human M1, M2, M3, or M5[1].
In vivo	VU0467154 produced a robust dose-dependent reversal of MK-801-induced hyperlocomotion and deficits in preclinical models of associative learning and memory functions, including the touchscreen pairwise visual discrimination task in wild-type mice, but failed to reverse these stimulant-induced deficits in M4 KO mice[1]. VU0467154 also enhanced the acquisition of both contextual and cue-mediated fear conditioning when administered alone in wild-type mice[1].

Chemical Properties

Molecular Weight	444.45
Formula	C₁₇H₁₅F₃N₄O₃S₂
Cas No.	1451993-15-9
Smiles	NC=1C=2C(SC1C(NCC3=CC=C(S(C(F)(F)F)(=O)=O)C=C3)=O)=NN=C(C)C2C
Relative Density.	1.514 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (123.75 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2500 mL	11.2499 mL	22.4997 mL	112.4986 mL
5 mM	0.4500 mL	2.2500 mL	4.4999 mL	22.4997 mL
10 mM	0.2250 mL	1.1250 mL	2.2500 mL	11.2499 mL
20 mM	0.1125 mL	0.5625 mL	1.1250 mL	5.6249 mL
50 mM	0.0450 mL	0.2250 mL	0.4500 mL	2.2500 mL
100 mM	0.0225 mL	0.1125 mL	0.2250 mL	1.1250 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc