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Benzethonium chloride

Catalog No. T0401 CAS 121-54-0

Synonyms: Hyamine, Phemeride, Quatrachlor

Benzethonium chloride (Quatrachlor) is a synthetic quaternary ammonium salt with surfactant, antiseptic, and broad spectrum antimicrobial properties.

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Benzethonium chloride Chemical Structure

Benzethonium chloride, CAS 121-54-0

Pack Size	Availability	Price/USD
50 mg	In stock	$ 36.00
100 mg	In stock	$ 51.00
200 mg	In stock	$ 68.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 97.5%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Benzethonium chloride (Quatrachlor) is a synthetic quaternary ammonium salt with surfactant, antiseptic, and broad spectrum antimicrobial properties.
Targets&IC50	α7 nAChR:122 nM, α4β2 nAChR:49 nM
In vitro	Administered in SCID mice bearing human laryngeal squamous cell carcinoma tumors, Benzethonium chloride (5 mg/kg) inhibited the growth of xenografts.
In vivo	In human hypopharyngeal squamous carcinoma cells, Benzethonium chloride at a concentration of 9 µM induces apoptosis and activates caspases after 12 hours. Furthermore, Benzethonium chloride at 5 µM enhances the effect of glucose consumption on the intracellular solute Ca(2+) concentration and its binding to membrane-associated proteins.
Cell Research	Cells are seeded in 96-well plates at 5,000 per well in 100 μL of growth medium and allowed to incubate for 24 hours. Benzethonium chloride is then added, as indicated, in a total volume of 5 μL. After 48 hours, MTS assay is done according to the specifications of the manufacturer, with DMSO (0.1%)–treated cells as negative control and cisplatin (166.6 μM)–treated cells as positive control.(Only for Reference)

Synonyms	Hyamine, Phemeride, Quatrachlor
Molecular Weight	448.09
Formula	C27H42ClNO2
CAS No.	121-54-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.4 mg/mL (49.99 mM)

H2O: 83 mg/mL (185.2 mM)

References and Literature

1. Coates KM, et al. Br J Pharmacol, 2001, 134(4), 871-879. 2. Zaman Z, et al. Eur J Clin Chem Clin Biochem, 1997, 35(8), 603-607. 3. Durieux ME, et al. Anesthesiology, 1997, 86(6), 1326-1333. 4. Lang E, et al. Cell Physiol Biochem, 2011, 28(2), 347-354. 5. Yip KW, et al. Clin Cancer Res, 2006, 12(18), 5557-5569.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Neurodegenerative Disease Compound Library Inactive Ingredient Library Neurotransmitter Receptor Compound Library Anti-Parkinson's Disease Compound Library FDA-Approved & Pharmacopeia Drug Library Bioactive Compound Library Anti-Alzheimer's Disease Compound Library NO PAINS Compound Library Neuronal Signaling Compound Library

Related Products

Related compounds with same targets

Solifenacin Picfeltarraegenin X LY2033298 ZSET1446 PQCA Pempidine Catestatin acetate Ursulcholic acid

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Keywords

Benzethonium chloride 121-54-0 Neuroscience AChR Hyamine Nicotinic acetylcholine receptors Inhibitor Phemeride Benzethonium nAChR inhibit Benzethonium Chloride Quatrachlor inhibitor

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