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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T12165 | nAChR agonist 1 | DUN71755 | AChR |
nAChR agonist 1 (DUN71755) is a brain-permeable and orally efficacious positive allosteric α7 nicotinic acetylcholine receptor (α7 nAChR)modulator. | |||
T39771 | nAChR agonist CMPI hydrochloride | ||
CMPI hydrochloride, a potent and selective nAChR agonist, functions as a positive allosteric modulator (PAM) specifically targeting the α4:α4 subunit interface of the nAChR. It enhances the response of the (α4)3(β2)2 nAC... | |||
T40177 | nAChR agonist 2 | ||
Compound 8, identified as a selective alpha4beta2 (α4β2) neuronal acetylcholine receptor (nAChR) agonist, demonstrates a dissociation constant (Kd) of 26 nM, indicating high affinity for this receptor subtype. | |||
T74396 | nAChR modulator-1 | ||
nAChR modulator-1, a insecticide, is a insect nAChR orthosteric modulator [1] . | |||
T74397 | nAChR modulator-2 | ||
nAChR modulator-2, a insecticide, is a insect nAChR orthosteric modulator [1] . | |||
T61064 | nAChR antagonist 1 | ||
nAChR antagonist 1 (compound B15) is a highly effective antagonist of α7 nAChR, demonstrating an IC50 value of 3.3 μM. Its versatility makes it an ideal candidate for investigating the pathogenesis of schizophrenia, Alzh... | |||
T62317 | α7 nAchR-JAK2-STAT3 agonist 1 | ||
α7 nAchR-JAK2-STAT3 agonist 1 is a potent inhibitor of the α7 nAchR-JAK2-STAT3 pathway that acts on nitric oxide (NO) (IC50: 0.32 μM). α7 nAchR-JAK2-STAT3 agonist 1 has been shown to have a positive effect on iNOS, IL-1β... | |||
T8868 | 4BP-TQS | AChR | |
4BP-TQS is an allosteric agonist of α7 nAChRs. | |||
T9542 | NS3861 | AChR | |
NS3861 is an agonist of nicotinic acetylcholine receptors (nAChRs) and bind with high affinity to heteromeric α3β4 and α4β2 nAChRs. NS3861 displays the β-subunit preference and a complete lack of activation at α4-contain... | |||
T17300 | (-)-(S)-B-973B | AChR | |
(-)-(S)-B-973B is an effective allosteric agonist and a positive allosteric modulator of α7 nAChR. | |||
T14094 | Acetamiprid | AChR | |
Acetamiprid is a nicotinic acetylcholine receptor (nAChR) agonist. Acetamiprid is a neonicotinoid insecticide used worldwide. It is shown to be associated with neuromuscular and reproductive disorders. | |||
T9076 | Spinosad | Others | |
Spinosad is a naturally-occurring insecticide found in the the soil bacterium S. spinosa. It is a mixture of the macrocyclic lactones spinosyn A and spinosyn D, which act as agonists of insect nicotinic acetylcholinester... | |||
T1594 | Vecuronium bromide | ORG NC 45 | AChR |
Vecuronium bromide (ORG NC 45) is a synthetic, intermediate-acting mono-quaternary steroid and non-depolarizing neuromuscular blocking agent, with muscle relaxant activity. | |||
T2422 | PNU-282987 | AChR | |
PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM). | |||
T7671 | Myosmine | Others , AChR | |
Myosmine is a minor tobacco alkaloid that is structurally related to nicotine. | |||
TQ0117 | A-867744 | AChR , Autophagy | |
A-867744 is an effective and selective type II positive allosteric modulator of the α7 nAChR (EC50: 1.0 μM). | |||
T7853 | (+)-Sparteine | Pachycarpine | AChR |
(+)-Sparteine (Pachycarpine) is a natural product extracted from scotch broom, is a sodium channel blocker and a class 1a antiarrhythmic agent | |||
T5S0994 | N-Methylcytisine | Caulophylline | Others , AChR |
1. N-Methylcytisine (Caulophylline)'s nicotinic receptors have high affinity (KD = 5 nM)to nAChR from squid optical ganglia. 2. N-Methylcytisine and N, N-dimethylcytisine did not displace 14C-tubocurarine at a concentrat... | |||
T37196 | 5-AAM-2-CP | AChR | |
5-AAM-2-CP is one of the major metabolites of Acetamiprid. Acetamiprid, a nAChR agonist, is a neonicotinoid insecticide used worldwide. | |||
T9787 | Suvn-911 | AChR | |
suvn-911 is a potent and selective antagonist of neuronal nicotinic acetylcholine α4β2 receptor (Ki = 1.5 nM) with antidepressant activity. |