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Medroxyprogesterone Acetate

Catalog No. T1261 CAS 71-58-9

Synonyms: Medroxyprogesterone 17-acetate, Provera, Metigestrona, NSC-26386, Farlutin, Medroxyprogesterone (acetate)

Medroxyprogesterone Acetate (Farlutin) is a synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been used to treat breast and endometrial neoplasms.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Medroxyprogesterone Acetate Chemical Structure

Medroxyprogesterone Acetate, CAS 71-58-9

Pack Size	Availability	Price/USD
100 mg	In stock	$ 55.00
500 mg	In stock	$ 65.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.45%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Medroxyprogesterone Acetate (Farlutin) is a synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been used to treat breast and endometrial neoplasms.
In vitro	Medroxyprogesterone acetate (MPA) and progesterone significantly reduced the levels of glutamic acid decarboxylase (GAD) in the hippocampus, while markedly increasing GAD levels in the olfactory cortex. In aged ovariectomized rats, MPA impaired the retention of delayed memory in the swim arm task and exacerbated overnight forgetting in the Morris water maze.
In vivo	Medroxyprogesterone acetate (MPA) reduces the secretion of IL-6 and PTHrP in human breast cancer cells and downregulates their expression in KTC-2 cells in a dose-dependent manner. In M-1 cells, MPA and dexamethasone increase the promoter-driven luciferase activity of α-ENaC in a dose-dependent fashion, an effect which is not inhibited by Org31710, indicating that MPA's regulation of α-ENaC is independent of the progesterone receptor (PR). Similarly, MPA and dexamethasone upregulate the mRNA of α-ENaC and SGK1 in both M-1 and Madin-Darby canine kidney-C7 cells, whereas progesterone does not exhibit this effect. At 0.1 nM, MPA significantly enhances the in vitro production of specific immunoglobulin G antibodies, an effect that seems to involve the interaction between progesterone and the PRG receptor. MPA also inhibits the enzyme 3-hydroxysteroid dehydrogenase, which is involved in the reversible conversion between THP and DHP, thereby potentially affecting the action of DHP and THP in the brain.

Synonyms	Medroxyprogesterone 17-acetate, Provera, Metigestrona, NSC-26386, Farlutin, Medroxyprogesterone (acetate)
Molecular Weight	386.52
Formula	C24H34O4
CAS No.	71-58-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL (25.9 mM)

Ethanol: 10 mg/mL (25.9 mM)

References and Literature

1. Ciriza I, et al. J Neurobiol,2006, 66(9), 916-928. 2. Kurebayashi J, et al. Thyroid, 2003, 13(3), 249-258. 3. Thomas CP, et al. Am J Physiol Renal Physiol. 2006 Feb;290(2):F306-12. 4. Vermeulen M, et al. Immunology,2001, 104(1), 80-86. 5. Braden BB, et al. Neurobiol Learn Mem, 2010, 93(3), 444-453. 6. Zhao Z, Zhao J, Liang N, et al. Deep eutectic solvent-based magnetic colloidal gel assisted magnetic solid-phase extraction: A simple and rapid method for the determination of sex hormones in cosmetic skin care toners[J]. Chemosphere. 2020: 127004.

Citations

1. Zhao Z, Zhao J, Liang N, et al. Deep eutectic solvent-based magnetic colloidal gel assisted magnetic solid-phase extraction: A simple and rapid method for the determination of sex hormones in cosmetic skin care toners. Chemosphere. 2020: 127004 2. Zhang C, Guo Q, Chen L, et al.A ribosomal gene panel predicting a novel synthetic lethality in non-BRCAness tumors.Signal Transduction and Targeted Therapy.2023, 8(1): 183.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Traditional Chinese Medicine Monomer Library Drug Repurposing Compound Library Bioactive Lipid Compound Library Orally Active Compound Library Transcription Factor-Targeted Compound Library Bioactive Compound Library Selected Plant-Sourced Compound Library

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Keywords

Medroxyprogesterone Acetate 71-58-9 Endocrinology/Hormones Metabolism Others Androgen Receptor Progesterone Receptor Estrogen/progestogen Receptor Glucocorticoid Receptor Endogenous Metabolite Medroxyprogesterone 17-acetate Provera Inhibitor NSC26386 Medroxyprogesterone Metigestrona NSC-26386 Farlutin NR3C3 inhibit NSC 26386 Medroxyprogesterone (acetate) inhibitor

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