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Isookanin

Catalog No. TN1788   CAS 1036-49-3

Isookanin shows strong diphenyl(2,4,6-trinitrophenyl)iminoazanium (DPPH) radical-scavenging activity with the IC50 value of 7.9 ± 0.53 μM. Isookanin is a potent inhibitor of α-amylase (IC50=0.447 mg/ml).

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Isookanin Chemical Structure
Isookanin, CAS 1036-49-3
Pack Size Availability Price/USD Quantity
1 mg In stock $ 50.00
5 mg In stock $ 124.00
10 mg In stock $ 197.00
25 mg In stock $ 345.00
1 mL * 10 mM (in DMSO) In stock $ 129.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Isookanin shows strong diphenyl(2,4,6-trinitrophenyl)iminoazanium (DPPH) radical-scavenging activity with the IC50 value of 7.9 ± 0.53 μM. Isookanin is a potent inhibitor of α-amylase (IC50=0.447 mg/ml).
Targets&IC50 DPPH:7.9 ± 0.53 μM, α-amylase:0.447 mg/ml
In vitro The chemical structures of these compounds were elucidated by extensive spectroscopic analysis and on the basis of their chemical reactivity. This work represents the first recorded example of the isolation of compounds 1??3, 6, 7, 9, 11, and 12 from C. tinctoria. Compounds 5??9 showed strong diphenyl(2,4,6-trinitrophenyl)iminoazanium (DPPH) radical-scavenging activity, with IC50 values of 3.35 ± 0.45, 9.6 ± 2.32, 4.12 ± 0.21, 6.2 ± 0.43, and 7.9 ± 0.53 μM, respectively. Compounds 2 and 8 exhibited angiotensin I-converting enzyme inhibitory activity, with IC50 values of 228 ± 4.47 and 145.67 ± 3.45 μM, respectively.
Molecular Weight 288.25
Formula C15H12O6
CAS No. 1036-49-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/ml (190.81 mM)

TargetMolReferences and Literature

1. Wang W, et al. New phenolic compounds from Coreopsis tinctoria Nutt. and their antioxidant and angiotensin i-converting enzyme inhibitory activities. J Agric Food Chem. 2015 Jan 14;63(1):200-7. 2. Abdullahi Aliyu, et al. Subacute Oral Administration of Clinacanthus nutans Ethanolic Leaf Extract Induced Liver and Kidney Toxicities in ICR Mice. Molecules. 2020 Jun 5;25(11):2631. 3. Xin Y, et al. Isookanin Inhibits PGE2-Mediated Angiogenesis by Inducing Cell Arrest through Inhibiting the Phosphorylation of ERK1/2 and CREB in HMEC-1 Cells. Int J Mol Sci. 2021 Jun 16;22(12):6466.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Natural Product Library Traditional Chinese Medicine Monomer Library Selected Plant-Sourced Compound Library Bioactive Compound Library Anti-Tumor Natural Product Library Bioactive Compounds Library Max Flavonoid Natural Product Library Anti-virus Traditional Chinese Medicine Monomer Library Anti-Viral Compound Library

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Keywords

Isookanin 1036-49-3 Metabolism Amylase skin snake bites diabetes HSV mellitus insects Herpes simplex virus cancer anti-viral rashes Clinacanthus nutans varicella-zoster Inhibitor inhibit virus diarrhoea inhibitor

 

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