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Britannin

Britannin
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Purity:98.53%
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Britannin

Catalog No. T5793Cas No. 33627-28-0
Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pathway in human breast cancer cells.
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Pack SizePriceAvailabilityQuantity
1 mg$58In Stock
2 mg$82In Stock
5 mg$133In Stock
10 mg$195In Stock
25 mg$327In Stock
50 mg$485In Stock
100 mg$693In Stock
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Product Introduction

Bioactivity
Description
Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pathway in human breast cancer cells.
In vitro
Britannin, a sesquiterpene lactone isolated from Asteraceae family, has antiproliferative activity on the MCF-7 and MDA-MB-468 human breast cancer cells. Annexin V/propidium iodide (PI) staining, Hoechst 33258 staining, and caspase-3/9 activity assay confirmed that britannin is able to induce apoptosis in MCF-7 and MDA-MB-468 cells. The expression of Bcl-2 was noticeably decreased in response to britannin treatment, while the expression of Bax protein was increased, which were positively correlated with elevated expression of p53. Moreover, britannin also increased reactive oxygen species (ROS) generation which in turn triggered the loss of mitochondrial transmembrane potential (ΔΨm) and the subsequent release of cytochrome c from mitochondria into cytosol.
Chemical Properties
Molecular Weight366.41
FormulaC19H26O7
Cas No.33627-28-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 45 mg/mL (122.81 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7292 mL13.6459 mL27.2918 mL136.4592 mL
5 mM0.5458 mL2.7292 mL5.4584 mL27.2918 mL
10 mM0.2729 mL1.3646 mL2.7292 mL13.6459 mL
20 mM0.1365 mL0.6823 mL1.3646 mL6.8230 mL
50 mM0.0546 mL0.2729 mL0.5458 mL2.7292 mL
100 mM0.0273 mL0.1365 mL0.2729 mL1.3646 mL

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