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2',5'-Dideoxyadenosine

2',5'-Dideoxyadenosine
2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor, binding to the P-site with an IC50 of 3 μM.
Catalog No. T10066Cas No. 6698-26-6
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Purity:99.55%
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2',5'-Dideoxyadenosine

Catalog No. T10066Cas No. 6698-26-6
2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor, binding to the P-site with an IC50 of 3 μM.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$33In Stock
5 mg$76In Stock
10 mg$122In Stock
25 mg$222In Stock
50 mg$372In Stock
100 mg$592In Stock
500 mg$1,290In Stock
1 mL x 10 mM (in DMSO)$84In Stock
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Product Introduction

Bioactivity
Description
2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor, binding to the P-site with an IC50 of 3 μM.
Targets&IC50
Adenylyl cyclase:3 µM
In vitro
2',5'-Dideoxyadenosine (20-150 mM), like adenosine, dependently and reversibly inhibits the positive inotropic and chronotropic effect of beta-adrenergic stimulation with isoproterenol (8-54 pmol) up to 70% and 50%, respectively [2]. 2',5'-Dideoxyadenosine (10 μM, 30 min) reduces cAMP production and blocks the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh). 2',5'-Dideoxyadenosine (10 μM, 30 min) blocks CCh-induced increase of phosphorylation of Akt and attenuates CCh-induced phosphorylation of Ser2448 [3].
In vivo
2',5'-Dideoxyadenosine (0.1 mg/kg; i.p.; 15 min pre-treated) completely inhibits the natriuretic, diuretic, and K+ and Cl- sparing effects of Fr-EtOAc in rats [4].
Cell Research
Primary hippocampal neurons. Concentration: 10 μM. Incubation Time: 30 min [3]
Animal Research
Male Wistar rats (3-4 months old).Dosage: 0.1 mg/kg.Administration: i.p.; 15 min pre-treated [3]
Chemical Properties
Molecular Weight235.24
FormulaC10H13N5O2
Cas No.6698-26-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 2.35 mg/mL (10 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.2510 mL21.2549 mL42.5098 mL212.5489 mL
5 mM0.8502 mL4.2510 mL8.5020 mL42.5098 mL
10 mM0.4251 mL2.1255 mL4.2510 mL21.2549 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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