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(RS)-(Tetrazol-5-yl)glycine

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Catalog No. T16801Cas No. 138199-51-6
Alias LY 285265, D,L-(tetrazol-5-yl)glycine

(RS)-(Tetrazol-5-yl)glycine is a potent and selective N-methyl-D-aspartate (NMDA) receptor agonist that can induce seizure models and Fos expression in mice. Its EC50 values for GluN1/GluN2D and GluN1/GluN2A are 99 nM and 1.7 μM, respectively.

(RS)-(Tetrazol-5-yl)glycine

(RS)-(Tetrazol-5-yl)glycine

😃Good
Catalog No. T16801Alias LY 285265, D,L-(tetrazol-5-yl)glycineCas No. 138199-51-6
(RS)-(Tetrazol-5-yl)glycine is a potent and selective N-methyl-D-aspartate (NMDA) receptor agonist that can induce seizure models and Fos expression in mice. Its EC50 values for GluN1/GluN2D and GluN1/GluN2A are 99 nM and 1.7 μM, respectively.
Pack SizePriceAvailabilityQuantity
5 mg$36Backorder
10 mg$58Backorder
25 mg$143Backorder
50 mg$247Backorder
100 mg$353Backorder
200 mg$495In Stock
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Product Introduction

Bioactivity
Description
(RS)-(Tetrazol-5-yl)glycine is a potent and selective N-methyl-D-aspartate (NMDA) receptor agonist that can induce seizure models and Fos expression in mice. Its EC50 values for GluN1/GluN2D and GluN1/GluN2A are 99 nM and 1.7 μM, respectively.
Targets&IC50
GluN1/GluN2A:1.7 μM(EC50), GluN1/GluN2D:(EC50)99 nM
In vitro
(RS)-(Tetrazol-5-yl)glycine does not significantly inhibit the binding of D,L-alpha-[5-methyl-3H] amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), [3H]kainate, or [3H]glycine (IC50s>30 μM). It displaces NMDA receptor binding to rat brain membranes using [3H]CGS19755 (IC50=98 nM) and [3H]glutamate (IC50=36 nM) as ligands [1].
In vivo
(RS)-(Tetrazol-5-yl)glycine is a potent convulsant in neonatal rats (ED50=0.071 mg/kg; i.p.) and induces seizure responses and Fos in NR1+/+ and NR1-/- mice (1.25, 1.5 mg/kg; IP) [1][3].
SynonymsLY 285265, D,L-(tetrazol-5-yl)glycine
Chemical Properties
Molecular Weight143.1
FormulaC3H5N5O2
Cas No.138199-51-6
SmilesNC(C(O)=O)c1nn[nH]n1
Relative Density.1.804 g/cm3
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: < 1.43 mg/mL (10 mM, insoluble or slightly soluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM6.9881 mL34.9406 mL69.8812 mL349.4060 mL
5 mM1.3976 mL6.9881 mL13.9762 mL69.8812 mL
10 mM0.6988 mL3.4941 mL6.9881 mL34.9406 mL

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Keywords

seizureNMDALY-285265LY285265Ionotropic glutamate receptorsInhibitorinhibitiGluRGluN2DGluN2AGluN1/GluN2DGluN1/GluN2AGluN1Fos(RS)-(Tetrazol-5-yl)glycine(RS)(Tetrazol5yl)glycine(RS) (Tetrazol 5 yl)glycine
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