regulator — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12218	NFAT Transcription Factor Regulator-1		IL Receptor
	NFAT Transcription Factor Regulator-1 is an synthesis inhibitor of IL-2 (IC50 of 182 nM).		IL Receptor
T60000	STING (WT/R232) activity regulator 126		STING
	STING (WT/R232) activity regulator 126 is a STING modulator with antibacterial and antiviral effects.		STING
T77804	KRAS G12D mutation regulator 4

T82450	ER proteostasis regulator-1
	ER Proteostasis Regulator-1 (Compound 481) is a potent modulator of endoplasmic reticulum proteostasis with research applications in Alzheimer's disease and diabetes [1].
T5637	Triflumuron		Others
	Triflumuron is an insecticide belonging to the group of so-called insect growth regulators. It inhibits the synthesis of chitin by the insect larvae, causing the die.		Others
T3135	KM11060		CFTR , Autophagy
	KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma membrane.		CFTR , Autophagy
T4384	Halofenozide		Others
	Halofenozide is an ecdysteroid agonist and used as a pesticide.		Others
T1805	Ataluren	PTC124	CFTR , Autophagy
	Ataluren (PTC124) is a novel, orally administered drug that targets nonsense mutations. Ataluren is approved for use by the European Medicines Agency to treat Duchenne Muscular Dystrophy in patients aged 5 years and olde...		CFTR , Autophagy
T1634	Glibenclamide	Glyburide	Potassium Channel , Mitochondrial Metabolism , CFTR , P-gp , Autophagy
	Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
T14898	CCG-63808		GTPase
	CCG-63808 is a reversible inhibitor of regulator of G-protein signaling (RGS) proteins. CCG-63808 dose-dependently inhibits the TR-FRET signal between RGS4-AF488 and Tb-Gαo with IC50 values of 1.9 μM.		GTPase
T16681	Nesolicaftor	PTI-428	CFTR , Autophagy
	Nesolicaftor (PTI-428) specifically enhances cystic fibrosis transmembrane conductance regulator protein synthesis.		CFTR , Autophagy
T14935	Elexacaftor	VX-445	CFTR , Autophagy
	Elexacaftor (VX-445) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) and it also facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface.		CFTR , Autophagy
T9499	Icenticaftor	QBW251	CFTR
	Icenticaftor (QBW251) is an orally active potentiator of CFTR channel.		CFTR
T11438	GNE-1858		Others , MAPK
	GNE-1858 is an ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor (IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA).		Others , MAPK
T14897	CCG-63802		GTPase
	CCG-63802 is a reversible inhibitor of the regulator of G-protein signaling (RGS) protein and has the greatest potency at RGS4.		GTPase
T5312	CFTR corrector 2	FDL169	CFTR , Autophagy
	CFTR corrector 2 (FDL169) is a novel and potent CFTR (Cystic fibrosis transmembrane conductance regulator) corrector for treating cystic fibrosis (CF) patients who carry the F508del mutation.		CFTR , Autophagy
T2451	GlyH-101	GlyH 101	CFTR , Autophagy
	GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.		CFTR , Autophagy
T3719	Daminozide	Succinic Acid,DMASA,Aminozide	Histone Demethylase
	Daminozide (Succinic Acid) is a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily.		Histone Demethylase
T1874	PPQ-102	PPQ102,CFTR Inhibitor,PPQ 102	CFTR , Autophagy
	PPQ-102 (CFTR Inhibitor), an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).		CFTR , Autophagy
T2588	Ivacaftor	Ivacaftor (VX-770),VX-770	CFTR , Autophagy
	Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells, respectively.		CFTR , Autophagy