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CCG-63808

Catalog No. T14898 CAS 620113-73-7

CCG-63808 is a reversible inhibitor of regulator of G-protein signaling (RGS) proteins. CCG-63808 dose-dependently inhibits the TR-FRET signal between RGS4-AF488 and Tb-Gαo with IC50 values of 1.9 μM.

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CCG-63808, CAS 620113-73-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CCG-63808 is a reversible inhibitor of regulator of G-protein signaling (RGS) proteins. CCG-63808 dose-dependently inhibits the TR-FRET signal between RGS4-AF488 and Tb-Gαo with IC50 values of 1.9 μM.
Targets&IC50	RGS4:1.9 μM
In vitro	CCG-63808 showed selectivity among RGS proteins with a potency order of RGS 4 > 19 = 16 > 8 ? 7. CCG-63808 inhibited the GTPase accelerating protein activity of RGS4[1].

Molecular Weight	454.48
Formula	C25H15FN4O2S
CAS No.	620113-73-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 1 mg/mL (2.20 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Levi L. Blazer et al.Reversible, Allosteric Small-Molecule Inhibitors of Regulator of G Protein Signaling Proteins. Molecular Pharmacology September 2010 vol.78 no.3 524-533

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Keywords

CCG-63808 620113-73-7 G蛋白偶联受体 GTPase CCG 63808 Regulators of G-protein Signaling RGS Protein inhibit CCG63808 Inhibitor Regulator of G-protein Signaling inhibitor

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