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CCG-63802

Catalog No. T14897 CAS 620112-78-9

CCG-63802 is a reversible small-molecule inhibitor of regulator of G protein signaling (RGS) proteins. CCG-63802 inhibits the interaction between RGS4 and Galpha with an IC50 value of 1.4 μM.

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CCG-63802, CAS 620112-78-9

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CCG-63802 is a reversible small-molecule inhibitor of regulator of G protein signaling (RGS) proteins. CCG-63802 inhibits the interaction between RGS4 and Galpha with an IC50 value of 1.4 μM.
Targets&IC50	RGS4:1.4 μM
In vitro	CCG-63802 inhibits GTPase accelerating protein activity of RGS4 and blocks its interaction with Gαo.

Molecular Weight	450.52
Formula	C26H18N4O2S
CAS No.	620112-78-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 1.67 mg/mL (3.71 mM), Need ultrasonic and warming

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Blazer LL, et al. Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins. Mol Pharmacol. 2010 Sep;78(3):524-33. 2. Meng X, et al. PPARγ Agonist PGZ Attenuates OVA-Induced Airway Inflammation and Airway Remodeling via RGS4 Signaling in Mouse Model. Inflammation. 2018 Jul 19. 3. Bosier B, et al. Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling. Br J Pharmacol. 2015 Nov;172(22):5333-46.

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Keywords

CCG-63802 620112-78-9 G蛋白偶联受体 GTPase inflammation RGS reversible selective CCG63802 Regulator of G-protein Signaling Regulators of G-protein Signaling inhibit Inhibitor CCG 63802 RGS Protein inhibitor

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