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Halofenozide

Catalog No. T4384 CAS 112226-61-6

Halofenozide is an ecdysteroid agonist and used as a pesticide.

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Halofenozide, CAS 112226-61-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 41.00
5 mg	In stock	$ 74.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 173.00
50 mg	In stock	$ 256.00
1 mL * 10 mM (in DMSO)	In stock	$ 97.00

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Purity: 99.32%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Halofenozide is an ecdysteroid agonist and used as a pesticide.

In vivo

The extremely slow excretion of the product in Colorado potato beetle (CPB) suggested that this fact must contribute to the prolonged action of halofenozide on fecundity at its highest dose of 20 μg per adult. Retention of halofenozide in the reproductive system of males of AMF and CPB was low, whereas high levels of radioactivity were recovered in females (ovaries + eggs) [1]. Topical application of 5 μg of the non-steroidal ecdysone agonist RH-0345 (halofenozide) in 0.1 μl DMSO to the primary reproductives during the 2000 season resulted in a significant reduction in the number of eggs laid. There was however complete recovery of the treated females In 2001 both topical application as well as feeding methods were tried. Significant effects were observed only in the topical treatment group, perhaps because of inconsistency in feeding. In this group, total progeny, the number of ovarioles in ovaries and the size of the female's corpora allata (CA) were all significantly reduced [2].

Molecular Weight	330.81
Formula	C18H19ClN2O2
CAS No.	112226-61-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (90.69 mM)

References and Literature

1. Farin s GP, et al. Action and pharmacokinetics of a novel insect growth regulator, halofenozide, in adult beetles of aubeonymus mariaefranciscae and leptinotarsa decemlineata. Arch Insect Biochem Physiol. 1999;41(4):201-13. 2. Raina AK, et al. Ecdysone agonist halofenozide affects corpora allata and reproductive physiology of the Formosan subterranean termite, Coptotermes formosanus. J Insect Physiol. 2003 Jul;49(7):677-83. 3. Li Y, Sun H, Tian Z, et al. The determination of Plutella xylostella (L.) GSTs (PxGSTs) involved in the detoxification metabolism of Tolfenpyrad[J]. Pest Management Science. 2020.

Citations

1. Li Y, Sun H, Tian Z, et al. The determination of Plutella xylostella (L.) GSTs (PxGSTs) involved in the detoxification metabolism of Tolfenpyrad. Pest Management Science. 2020

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compounds Library Max Bioactive Compound Library Human Metabolite Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Halofenozide 112226-61-6 Others regulator Inhibitor inhibit Tenebrio Ovaries RH 0345 RH-0345 RH0345 molitor Mealworm insect growth ecdysteroid hormone 20-hydroxyecdysone ecdysone Ecdysteroids inhibitor

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