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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8929 | BC1618 | 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]- | Mitophagy , Others , E1/E2/E3 Enzyme , AMPK |
BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) is an orally active Fbxo48 inhibitor that stimulates Ampk-dependent signaling. It promotes mitochondrial fission, promotes autophagy and imp... | |||
T8843 | APS6-45 | MAPK , Ras | |
APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity. | |||
T16567 | PQR530 | PQR-530 | PI3K , mTOR |
PQR530 is a highly potent dual pan-PI3K/mTORC1/2 inhibitor. PQR530 inhibited protein kinase B (PKB, pSer473) and ribosomal protein S6 (pS6, pSer235/236) phosphorylation with IC50 values of 0.07 μM. It also showing antitu... | |||
T40319 | PIM-IN-1 | ||
PIM-IN-1 is a pan-PIM kinase inhibitor (KG-1, EC 50 = 61 nM; pS6, EC 50 = 71 nM). | |||
T1961 | Vistusertib | AZD2014 | Apoptosis , Akt , PI3K , S6 Kinase , mTOR , Autophagy |
Vistusertib (AZD2014) is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. | |||
T79211 | MTOR inhibitor-11 | mTOR | |
mTOR inhibitor-11 (Compound 9) is a brain-penetrant compound capable of inhibiting mTOR with an IC50 of 21 nM for pS6. It also exhibits inhibitory activity against pCHK1 and PDE4D with IC50 values of 17.2 μM and 17.0 μM,... | |||
T70782 | PF-05139962 | ||
PF-05139962 is a novel potent mTOR inhibitor with excellent mTOR biochemical inhibition, cellular potency, kinase selectivity and in vitro ADME properties. PF-05139962 has pS473 and pS6 cellular IC50 = 48 and 6 nM respec... |