Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PQR530 is a highly potent dual pan-PI3K/mTORC1/2 inhibitor. PQR530 inhibited protein kinase B (PKB, pSer473) and ribosomal protein S6 (pS6, pSer235/236) phosphorylation with IC50 values of 0.07 μM. It also showing antitumor activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 48.00 | |
5 mg | In stock | $ 113.00 | |
10 mg | In stock | $ 163.00 | |
25 mg | In stock | $ 328.00 | |
50 mg | In stock | $ 488.00 | |
100 mg | In stock | $ 713.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 125.00 |
Description | PQR530 is a highly potent dual pan-PI3K/mTORC1/2 inhibitor. PQR530 inhibited protein kinase B (PKB, pSer473) and ribosomal protein S6 (pS6, pSer235/236) phosphorylation with IC50 values of 0.07 μM. It also showing antitumor activity. |
Targets&IC50 | mTOR:0.33 nM (Kd), PI3Kγ:10 nM (Kd), PI3Kα:0.84 nM (Kd), PI3Kβ:6.1 nM (Kd), PI3KC2β:100 nM (Kd), PI3Kδ:11 nM (Kd) |
In vitro | PQR-530 inhibits all PI3K isoforms and mTOR complexes C1/2 potently and selectively. PQR-530 inhibits protein kinase B (PKB, pSer473) and ribosomal protein S6 (pS6, pSer235/236) phosphorylation (IC50: 0.07 μM in A2058 melanoma cells). PQR-530 displays inhibitory activity against the growth of 44 cancer cell lines (mean GI50: 426 nM)[1]. |
Synonyms | PQR-530 |
Molecular Weight | 407.42 |
Formula | C18H23F2N7O2 |
CAS No. | 1927857-61-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (61.36 mM)
You can also refer to dose conversion for different animals. More
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PQR530 1927857-61-1 PI3K/Akt/mTOR signaling mTOR PI3K Inhibitor PQR-530 Phosphoinositide 3-kinase PQR 530 inhibit Mammalian target of Rapamycin inhibitor