overactive — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5023	Propiverine hydrochloride		Others , Calcium Channel , AChR
	Propiverine is a widely used antimuscarinic drug with a mixed mode of action in the treatment of symptoms associated with overactive bladder (OAB).		Others , Calcium Channel , AChR
T19723	AMTB hydrochloride	AMTB	TRP/TRPV Channel
	AMTB hydrochloride (AMTB HCl) is a novel TRPM8 channel blocker and is effective for pain and urinary diseases. AMTB can act on the bladder afferent pathway to attenuate the bladder micturition reflex and nociceptive refl...		TRP/TRPV Channel
T9419	Fesoterodine	(R) Fesoterodine	AChR
	Fesoterodine ((R) Fesoterodine) is an orally active, competitive mAChR antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. It is used for the overactive bladder (OAB).		AChR
T4612	NS309		EGFR , Potassium Channel , HER
	NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK channels and 10-90 nM for IK channels). It can also activat...		EGFR , Potassium Channel , HER
T1472	Trospium chloride	Spasmex,Sanctura	AChR
	Trospium chloride (Spasmex) is an antispasmodic and anticholinergic agent used to treat urinary incontinence and overactive bladder syndrome. Trospium chloride has not been implicated in causing liver enzyme elevations o...		AChR
T1475	Fesoterodine fumarate	Toviaz,SPM 907	AChR
	Fesoterodine fumarate (Toviaz) is the fumarate salt form of fesoterodine, a competitive muscarinic receptor antagonist with muscle relaxant and urinary antispasmodic properties. Fesoterodine is rapidly hydrolyzed in vivo...		AChR
T0703	Flavoxate hydrochloride	Flavoxate HCl,NSC-114649,DW61,Rec-7-0040	AChR
	Flavoxate hydrochloride (DW61) , a muscarinic AChR antagonist, is used in the therapy of various urinary syndromes and as an antispasmodic.		AChR
T1671	Mirabegron	YM178	Adrenergic Receptor
	Mirabegron (YM178) is a beta-3 adrenergic agonist that is used for treatment of overactive bladder syndrome.		Adrenergic Receptor
T15273	Fedovapagon	VA483,A106483	Vasopressin Receptor
	Fedovapagon (VA106483) is a selective and potent agonist of the vasopressin V2 receptor (V2R) that inhibits the growth of intersegmental vessels in zebrafish. Fedovapagon can be used to study overactive bladder, nocturia...		Vasopressin Receptor
T1534	Darifenacin hydrobromide	Darifenacin HBr,UK-88525	AChR
	Darifenacin hydrobromide (UK-88525) is a selective muscarinic receptor antagonist used to treat urinary incontinence and overactive bladder syndrome.		AChR
T1049L	Oxybutynin	Oxytrol,Ditropan,Oxibutyninum	Potassium Channel , AChR
	Oxybutynin (Ditropan) is a synthetic anticholinergic agent that is used for treatment of urinary incontinence and overactive bladder syndrome.		Potassium Channel , AChR
T12970	Solabegron	GW 427353	Adrenergic Receptor
	Solabegron (GW 427353) is a selective agonist of β3-adrenergic receptor, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR(EC50 : 22 nM). It is used for treatment of overactive bladd...		Adrenergic Receptor
T76690	Mavrilimumab	CAM 3001	Virus Protease , CSF-1R
	Mavrilimumab (CAM 3001) is a monoclonal antibody with antiviral activity that has an affinity for the α subunit of the granulocytic-macrophage colony-stimulating factor (GM-CSF) receptor and blocks downstream intracellul...		Virus Protease , CSF-1R
T11275	Fesoterodine L-mandelate		Others
	Fesoterodine L-mandelate is a efficacious antimuscarinic agent for the overactive bladder (OAB).		Others
T35052	Vibegron	MK4618,MK 4618,MK-4618
	Vibegron (MK-4618) is an effective and selective Beta 3 adrenergic receptor agonist, used to treat overactive bladder (OAB).
T70338	Lu AF58786
	Lu AF58786 is a novel potent and selective inhibitor of LRRK2, inhibiting LRRK2 WT, the overactive variant G2019S, and the resistant mutant A2016T56 at 12 nM, 19 nM and 93 nM, respectively.
T28465	PSD-506	PSD 506,RO 3202904,RO3202904,RO-3202904
	PSD-506, a muscarinic M2/M3 antagonist, is used potentially for the treatment of overactive bladder, and urinary incontinence.
T28125	N-5984	N5984,KRP-204,KRP 204,KRP204
	N-5984, a β3-adrenergic receptor agonist, is used potentially for the treatment of obesity, overactive bladder and type 2 diabetes.
T29208	ZD-0947	AZD0947,AZD-0947,ZD 0947,AZD 0947
	ZD-0947, a K(ATP) channel activator, is used potentially for the treatment of overactive bladder (OAB).
T68548	Tolterodine Dimer
	Tolterodine Dimer is a derivative of Tolterodine -- a muscarinic receptor antagonist that is used to treat patients with overactive bladder.