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Mirabegron

Catalog No. T1671   CAS 223673-61-8
Synonyms: YM178

Mirabegron (YM178) is a beta-3 adrenergic agonist that is used for treatment of overactive bladder syndrome.

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Mirabegron Chemical Structure
Mirabegron, CAS 223673-61-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 30.00
2 mg In stock $ 44.00
5 mg In stock $ 68.00
10 mg In stock $ 117.00
25 mg In stock $ 203.00
50 mg In stock $ 369.00
100 mg In stock $ 531.00
500 mg In stock $ 1,180.00
1 mL * 10 mM (in DMSO) In stock $ 75.00
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Purity: 99.14%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Mirabegron (YM178) is a beta-3 adrenergic agonist that is used for treatment of overactive bladder syndrome.
Targets&IC50 β3-adrenoceptor:22.4 nM(EC50)
Cell Research Mirabegron (YM178) is dissolved in 100% DMSO and diluted with assay buffer[1]. CHO cells (105) are seeded in each well of a 24-well culture plate and subcultured. Three days later, the medium is exchanged with 250 μL/well Hanks' balanced salt solution containing 0.1 mM 3-isobutyl-1-methylxanthine, pH 7.4. The cells are incubated with each compound (isoproterenol, Mirabegron, BRL37344, and CL316,243 at final concentrations of 10-10 to 10-4 M) for 10 min at 37°C, after which incubation is stopped by the addition of 250 μL of 0.2 M HCl. cAMP concentration in the reaction mixture is measured by radioimmunoassay using an 125I-cAMP assay system using a gamma counter. Fifty microliters of reaction mixture is incubated with 50 μL of succinyl agent for 10 min at room temperature, after which the reaction is stopped by the addition of 400 μL of buffer solution. Fifty microliters of succinylated sample is incubated with 50 μL of 125I-cAMP and 50 μL of anti-cAMP antibody for 24 h at 4°C. At the end of the incubation period, 250 μL of charcoal suspension is added and centrifuged for 10 min at 2800 g at 4°C. Two hundred and fifty microliters of supernatant is transferred into a tube and counted for 1 min using a gamma counter. The intrinsic activity (I.A.) relative to isoproterenol for each β-adrenoceptor agonist is calculated using the maximal response of each compound[1].
Synonyms YM178
Molecular Weight 396.51
Formula C21H24N4O2S
CAS No. 223673-61-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 8 mg/mL (20.17 mM)

DMSO: 73 mg/mL (184.1 mM)

TargetMolReferences and Literature

1. Takasu T, et al. J Pharmacol Exp Ther, 2007, 321(2), 642-647. 2. Takusagawa S, et al. Xenobiotica, 2012, 42(12), 1187-1196. 3. Aizawa N, et al. Eur Urol, 2012, 62(6):1165-1173. 4. Hatanaka T, et al. Naunyn Schmiedebergs Arch Pharmacol, 2013, 386(1), 71-78.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Neurodegenerative Disease Compound Library GPCR Compound Library NO PAINS Compound Library Clinical Compound Library Immunology/Inflammation Compound Library FDA-Approved Drug Library Endocrinology-Hormone Compound Library

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Keywords

Mirabegron 223673-61-8 GPCR/G Protein Neuroscience Adrenergic Receptor Inhibitor cAMP CHO YM 178 YM-178 YM178 inhibit Beta Receptor inhibitor

 

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