noncovalent — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11464	GRL0617		SARS-CoV , DUB
	GRL0617 is a selective and competitive SARS-CoVPLpro and deubiquitinase noncovalent inhibitor(IC50 : 0.6 μM, Ki : 0.49 μM).		SARS-CoV , DUB
T3224	TBA-7371	AZ 7371,DprE1-IN-1	Antibacterial , PDE , DprE1
	TBA-7371 (DprE1-IN-1) is a potent inhibitor of DprE1 and PDE6.		Antibacterial , PDE , DprE1
T8371	ML188		Virus Protease , SARS-CoV
	ML188 is a selective noncovalent SARS-CoV 3CLpro inhibitor(IC50 : 1.5 μM), with moderate MW and good enzyme and antiviral inhibitory activity.		Virus Protease , SARS-CoV
T36038	SY-5609	CDK7-IN-3	CDK
	SY-5609 is a selective and noncovalent inhibitor of CDK7(KD = 0.065 nM) with antitumor activity and inhibits apoptosis.		CDK
T17220	Vecabrutinib	SNS-062	Tyrosine Kinases , BTK
	Vecabrutinib (SNS-062) is a potent and noncovalent BTK and ITK inhibitor (Kd: 0.3 nM and 2.2 nM, respectively). Vecabrutinib displays an IC50 of 24 nM for ITK.		Tyrosine Kinases , BTK
T15282	Filibuvir	PF-00868554	HCV Protease , DNA/RNA Synthesis
	Filibuvir (PF-00868554) is a selective and noncovalent inhibitor of HCV NS5B RNA-dependent RNA polymerase. Filibuvir inhibits genotype 1a and 1b replicons with EC50s of 59 nM.		HCV Protease , DNA/RNA Synthesis
TQ0242	Fenebrutinib	GDC-0853	BTK
	Fenebrutinib (GDC-0853) is a selective and noncovalent Btk inhibitor (Ki: 0.91 nM).		BTK
T60095	CCF0058981		SARS-CoV
	CCF0058981 (CCF981) is a 3-chlorophenyl analogue, serving as a noncovalent inhibitor of SARS-CoV-2 3CL pro (SC2), demonstrating potent activity with an IC50 of 68 nM. It also exhibits inhibitory effects against SARS-CoV-...		SARS-CoV
T27661	JNJ-10329670
	JNJ 10329670 is a highly potent (Ki of approximately 30 nM), nonpeptidic, noncovalent inhibitor of human cathepsin S with immunosuppressive activity.
T79294	NC-R17		Glutathione Peroxidase
	NC-R17, an RSL3-based noncovalent GPX4 degrader implicated in ferroptosis, demonstrates anti-tumor activity and is utilized in the design of noncovalent GPX4-targeted proteolysis targeting chimeras (PROTACs) [1].		Glutathione Peroxidase
T70668	GNE-431
	GNE-431 is a potent, selective and noncovalent Btk inhibitor with IC50 of 3.2 nM. GNE-431 showed excellent potency against the C481R, T474I, and T474M mutants. GNE-431 may provide a treatment option to patients, especia...
T79654	CRM1-IN-1		CRM1
	CRM1-IN-1 (Compound KL1), a noncovalent inhibitor of CRM1, promotes nuclear degradation of CRM1 with an IC50 of 0.27 μM, inhibits CRM1-mediated nuclear export, suppresses cell proliferation, and induces apoptosis in colo...		CRM1
T79604	SHR5428		CDK
	SHR5428 is an orally active, selective, noncovalent inhibitor of CDK7, displaying potent enzymatic inhibition (IC50 = 2.3 nM) and effectively suppressing cellular activity in triple-negative breast cancer MDA-MB-468 cell...		CDK
T79655	CRM1-IN-2		CRM1
	CRM1-IN-2 (Compound KL2) is a noncovalent inhibitor that targets CRM1, localizing it to the nuclear periphery, depleting its nuclear presence, and inhibiting its nuclear export function. It demonstrates the capability to...		CRM1
T81500	PF-07059013
	PF-07059013, an orally active and potent noncovalent modulator of sickled hemoglobin (HbS), specifically binds to Hb with nanomolar affinity and demonstrates substantial partitioning into red blood cells (RBCs), making i...
T73205	Praelolide
	Praelolide, a potent Nrf2 activator, disrupts Keap1-Nrf2 protein-protein interactions through noncovalent binding to Keap1, inhibiting osteoclastogenesis and the production of reactive oxygen species (ROS). With its pote...
T79455	SARS-CoV-2 Mpro-IN-9		SARS-CoV
	SARS-CoV-2 Mpro-IN-9 (compound c7), a nonpeptidic, noncovalent inhibitor of SARS-CoV-2 main protease (Mpro), exhibits potent inhibitory action (IC50 = 0.085 μM) and improved physicochemical and drug metabolism and pharma...		SARS-CoV
T79319	OATD-02		Arginase
	OATD-02 is an orally active, competitive, reversible, noncovalent inhibitor with slow offset kinetics that targets both Arginase1 and 2, exhibiting inhibitory concentrations (IC50) of 20 nM (hARG1), 39 nM (hARG2), 39 nM ...		Arginase
T75133	NRX-0492
	NRX-0492 is an orally administered compound that efficiently degrades Bruton's tyrosine kinase (BTK) by catalyzing its ubiquitylation and subsequent proteasomal degradation, achieving half-maximal degradation concentrati...