non-nucleoside — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9103	BVDV-IN-1		DNA/RNA Synthesis
	BVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM. It directly binds to a hydrophobic pocket of the BVDV RdRp. It has antiviral activity against BVDV resistant to...		DNA/RNA Synthesis
T6729	Lomibuvir	VX-222,VCH-222	HCV Protease
	Lomibuvir (VCH-222) (VX-222) is a selective, non-nucleoside allosteric inhibitor of HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC 50 of 5.2 nM. Lomibuvir...		HCV Protease
T2330	Rilpivirine	TMC278,R278474,DB08864	HIV Protease , Reverse Transcriptase
	Rilpivirine (R278474) is a diarylpyrimidine derivative and reverse transcriptase inhibitor with antiviral activity against HIV-1 that is used in the treatment of HIV infections.		HIV Protease , Reverse Transcriptase
T7700	Lersivirine	Lersivirine(UK 453061),UK-453061	HIV Protease , Reverse Transcriptase
	Lersivirine (UK-453061)(UK 453061) is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) under development for HIV infection therapy.		HIV Protease , Reverse Transcriptase
T2393	Efavirenz	EFV,DMP 266,Sustiva,Stocrin,L-743726	HIV Protease , Reverse Transcriptase , Autophagy
	Efavirenz (DMP 266) is a Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor. The mechanism of action of efavirenz is as a Non-Nucleoside Reverse Transcriptase Inhibitor, and Cytochrome P...		HIV Protease , Reverse Transcriptase , Autophagy
T3172	Trovirdine	LY300046	HIV Protease
	Trovirdine (LY300046) is a thiourea non-nucleoside reverse transcriptase inhibitor.		HIV Protease
T1815	Dapivirine	R147681,TMC120	Apoptosis , HIV Protease , Reverse Transcriptase , Autophagy
	Dapivirine (R147681) is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor.
T68103L	Mk-6186 HCl	Mk-6186 HCl（1034474-19-5 Free base)	HIV Protease , Reverse Transcriptase
	MK-6186 HCl, a novel non-nucleoside reverse transcriptase inhibitor with antiviral activity, can be used to study HIV.		HIV Protease , Reverse Transcriptase
T68103	MK-6186		Reverse Transcriptase
	MK-6186 is a novel non-nucleoside reverse transcriptase inhibitor with antiviral activity for the study of viral infections.		Reverse Transcriptase
T31860	Fosdevirine	GSK-2248761A,IDX 899,GSK 2248761A,GSK 2248761,GSK-2248761,IDX-12899,GSK2248761,FDV,GSK2248761A	HIV Protease
	Fosdevirine (GSK2248761) is a selective and potent non-nucleoside reverse transcriptase (NNRTI) inhibitor with anti-HIV activity for the study of neurological related disorders such as late-onset epilepsy.		HIV Protease
T67788	BAY-43-9695		HCV Protease
	BAY-43-9695 is a non-nucleoside compound with anti-human cytomegalovirus (HCMV) activity. It is the major metabolite of BAY-38-4766.		HCV Protease
T67804	KM-023		HIV Protease
	KM-023 is a new second-generation non-nucleoside reverse transcriptase inhibitor for the study of human immunodeficiency virus (HIV) type 1 infection.		HIV Protease
T16674	Pseudouridine		Endogenous Metabolite
	Pseudouridine is the most abundant modified nucleoside in non-coding RNAs. It enhances the function of transfer RNA and ribosomal RNA by stabilizing RNA structure.		Endogenous Metabolite
T3632	Doravirine	MK-1439	HIV Protease , Reverse Transcriptase
	Doravirine (MK-1439) is a non-nucleoside reverse transcriptase inhibitor, used in the treatment of HIV/AIDS.		HIV Protease , Reverse Transcriptase
T7212	Delavirdine mesylate	U 90152 (mesylate),BHAP-U 90152 (mesylate),Delavirdine (mesylate)	HIV Protease , Reverse Transcriptase
	Delavirdine mesylate (BHAP-U 90152 (mesylate)) is a non-nucleoside reverse transcriptase inhibitor (NNRTI).		HIV Protease , Reverse Transcriptase
T1595	Nevirapine	NSC 641530,BI-RG 587,NVP	HIV Protease , Reverse Transcriptase
	Nevirapine (NVP) is a benzodiazepine non-nucleoside reverse transcriptase inhibitor. In combination with other antiretroviral drugs, nevirapine reduces HIV viral loads and increases CD4 counts, thereby retarding or preve...		HIV Protease , Reverse Transcriptase
T3489	Dasabuvir	ABT-333	HCV Protease
	Dasabuvir (ABT-333) is a non-nucleoside inhibitor of the hepatitis C virus (HCV) non-structural protein 5B (NS5B), an RNA-dependent RNA polymerase, with potential activity against HCV. Upon administration and after intra...		HCV Protease
T31860L	(Iso)-Fosdevirine	(Iso)-Fosdevirine（Iso-1018450-26-4）,(Iso)-GSK2248761	HIV Protease
	(Iso)-Fosdevirine ( (Iso)-GSK2248761) is a selective and potent non-nucleoside reverse transcriptase (NNRTI) inhibitor with anti-HIV activity for the study of neurological disorders such as late-onset epilepsy.		HIV Protease
T29037	UC-781	NSC 675186,UC781,UC 781	Antiviral , HIV Protease
	UC-781 (NSC-675186) is a potent and selective inhibitor of human immunodeficiency virus HIV-1 non-nucleoside reverse transcriptase (NNRTI) I with a C50 value of 5 nM.UC-781 exhibits both antiviral activity and drug resis...		Antiviral , HIV Protease
T2551	Etravirine	TMC125,R165335	HIV Protease , Reverse Transcriptase
	Etravirine (R165335) is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor. Etravirine is designed to be active against HIV isolates with mutations that confer resistance to the two most commonly prescribe...		HIV Protease , Reverse Transcriptase