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Lomibuvir

Catalog No. T6729   CAS 1026785-55-6
Synonyms: VX-222, VCH-222

Lomibuvir (VCH-222) (VX-222) is a selective, non-nucleoside allosteric inhibitor of HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC 50 of 5.2 nM. Lomibuvir preferentially inhibits elongative RNA synthesis rather than de novo -initiated RNA synthesis [1].

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Lomibuvir Chemical Structure
Lomibuvir, CAS 1026785-55-6
Pack Size Availability Price/USD Quantity
1 mg In stock $ 41.00
5 mg In stock $ 97.00
10 mg In stock $ 172.00
25 mg In stock $ 313.00
50 mg In stock $ 522.00
100 mg In stock $ 813.00
1 mL * 10 mM (in DMSO) In stock $ 107.00
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Purity: 100%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Lomibuvir (VCH-222) (VX-222) is a selective, non-nucleoside allosteric inhibitor of HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC 50 of 5.2 nM. Lomibuvir preferentially inhibits elongative RNA synthesis rather than de novo -initiated RNA synthesis [1].
Targets&IC50 HCV NS5B 1a:0.94-1.2 μM
In vitro Lomibuvir (VX-222) is an effective non-nucleoside, allosteric inhibitor of the hepatitis C virus NS5B polymerase, exhibiting strong clinical efficacy. It demonstrates potent inhibition against the wild-type HCV 1b/Con1 replicon with an EC50 of 5.2 nM and against mutant replicons M423T, L419M, and I482L with EC50s of 79.8, 563.1, and 45.3 nM, respectively. Besides slightly hindering de novo initiation, Lomibuvir prominently impairs primer extension, illustrated by an IC50 of 31 nM for primer-extended RNA synthesis.
Synonyms VX-222, VCH-222
Molecular Weight 445.61
Formula C25H35NO4S
CAS No. 1026785-55-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 82 mg/mL (184 mM)

DMSO: 82 mg/mL (184 mM)

TargetMolReferences and Literature

1. Bedard J, et al. J Hepatol, 2009, 50(Suppl 1), S340. 2. Yi G, et al. Antimicrob Agents Chemother, 2012, 56(2), 830-837. 3. Chauret N, et al. J Hepatol, 2009, 50(Suppl 1), S341-S342.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compounds Library Max Inhibitor Library Clinical Compound Library Immunology/Inflammation Compound Library Anti-Viral Compound Library Bioactive Compound Library ReFRAME Related Library Drug Repurposing Compound Library Human Metabolite Library Anti-Aging Compound Library

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Keywords

Lomibuvir 1026785-55-6 Microbiology/Virology Proteases/Proteasome HCV Protease VCH222 RdRp cis-Lomibuvir cis-isomer DNA/RNA Synthesis VCH 222 VX 222 VX-222 VCH-222 HCV inhibit Inhibitor VX222 non-nucleoside polymerase Hepatitis C virus inhibitor

 

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