Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lomibuvir (VCH-222) (VX-222) is a selective, non-nucleoside allosteric inhibitor of HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC 50 of 5.2 nM. Lomibuvir preferentially inhibits elongative RNA synthesis rather than de novo -initiated RNA synthesis [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 41.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 172.00 | |
25 mg | In stock | $ 313.00 | |
50 mg | In stock | $ 522.00 | |
100 mg | In stock | $ 813.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 107.00 |
Description | Lomibuvir (VCH-222) (VX-222) is a selective, non-nucleoside allosteric inhibitor of HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC 50 of 5.2 nM. Lomibuvir preferentially inhibits elongative RNA synthesis rather than de novo -initiated RNA synthesis [1]. |
Targets&IC50 | HCV NS5B 1a:0.94-1.2 μM |
In vitro | Lomibuvir (VX-222) is an effective non-nucleoside, allosteric inhibitor of the hepatitis C virus NS5B polymerase, exhibiting strong clinical efficacy. It demonstrates potent inhibition against the wild-type HCV 1b/Con1 replicon with an EC50 of 5.2 nM and against mutant replicons M423T, L419M, and I482L with EC50s of 79.8, 563.1, and 45.3 nM, respectively. Besides slightly hindering de novo initiation, Lomibuvir prominently impairs primer extension, illustrated by an IC50 of 31 nM for primer-extended RNA synthesis. |
Synonyms | VX-222, VCH-222 |
Molecular Weight | 445.61 |
Formula | C25H35NO4S |
CAS No. | 1026785-55-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 82 mg/mL (184 mM)
DMSO: 82 mg/mL (184 mM)
You can also refer to dose conversion for different animals. More
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Lomibuvir 1026785-55-6 Microbiology/Virology Proteases/Proteasome HCV Protease VCH222 RdRp cis-Lomibuvir cis-isomer DNA/RNA Synthesis VCH 222 VX 222 VX-222 VCH-222 HCV inhibit Inhibitor VX222 non-nucleoside polymerase Hepatitis C virus inhibitor