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Fosdevirine

Catalog No. T31860 CAS 1018450-26-4

Synonyms: GSK-2248761A, IDX 899, GSK 2248761A, GSK 2248761, GSK-2248761, IDX-12899, GSK2248761, FDV, GSK2248761A

Fosdevirine (GSK2248761) is a selective and potent non-nucleoside reverse transcriptase (NNRTI) inhibitor with anti-HIV activity for the study of neurological related disorders such as late-onset epilepsy.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Fosdevirine, CAS 1018450-26-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 195.00
5 mg	In stock	$ 483.00
10 mg	In stock	$ 692.00
25 mg	In stock	$ 1,080.00
50 mg	In stock	$ 1,490.00

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Purity: 99.94%

ee: 99.58%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Fosdevirine (GSK2248761) is a selective and potent non-nucleoside reverse transcriptase (NNRTI) inhibitor with anti-HIV activity for the study of neurological related disorders such as late-onset epilepsy.
In vitro	Fosdevirine demonstrates potent in vitro antiviral efficacy against single-point mutations K103N and Y181C, and is similarly effective against the majority of double mutants[1].

Synonyms	GSK-2248761A, IDX 899, GSK 2248761A, GSK 2248761, GSK-2248761, IDX-12899, GSK2248761, FDV, GSK2248761A
Molecular Weight	413.79
Formula	C20H17ClN3O3P
CAS No.	1018450-26-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Castellino S, et al. Central nervous system disposition and metabolism of Fosdevirine (GSK2248761), a non-nucleoside reverse transcriptase inhibitor: an LC-MS and Matrix-assisted laser desorption/ionization imaging MS investigation into central nervous system toxicity. Chem Res Toxicol. 2013 Feb 18;26(2):241-51. 2. Margolis DA, Eron JJ, DeJesus E, White S, Wannamaker P, Stancil B, Johnson M. Unexpected finding of delayed-onset seizures in HIV-positive, treatment-experienced subjects in the Phase IIb evaluation of fosdevirine (GSK2248761). Antivir Ther. 2014;19(1):69-78. doi: 10.3851/IMP2689. Epub 2013 Oct 24. PubMed PMID: 24158593. 3. Ölgen S. Recent development of new substituted indole and azaindole derivatives as anti-HIV agents. Mini Rev Med Chem. 2013 Oct;13(12):1700-8. Review. PubMed PMID: 23895189.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Fosdevirine 1018450-26-4 Microbiology/Virology Proteases/Proteasome HIV Protease GSK-2248761A IDX 899 GSK 2248761A GSK 2248761 GSK-2248761 IDX-12899 GSK2248761 FDV GSK2248761A inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.