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BVDV-IN-1

Catalog No. T9103 CAS 345651-04-9

BVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM. It directly binds to a hydrophobic pocket of the BVDV RdRp. It has Antiviral activity against BVDV resistant to NNI thiosemicarbazone (TSC).

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BVDV-IN-1, CAS 345651-04-9

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM. It directly binds to a hydrophobic pocket of the BVDV RdRp. It has antiviral activity against BVDV resistant to NNI thiosemicarbazone (TSC).
In vitro	BVDV-IN-1?has antiviral activity against BVDV resistant to NNI thiosemicarbazone (TSC). It is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM. It directly binds to a hydrophobic pocket of the BVDV RdRp.

Molecular Weight	334.42
Formula	C20H22N4O
CAS No.	345651-04-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 250 mg/mL (747.59 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Gabriela A Fernández, et al. Design and Optimization of Quinazoline Derivatives: New Non-nucleoside Inhibitors of Bovine Viral Diarrhea Virus. Front Chem. 2020 Dec 10;8:590235.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BVDV-IN-1 345651-04-9 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis inhibit virus non-nucleoside BVDV IN 1 activity bovine viral antiviral inhibitor BVDVIN1 diarrhea Inhibitor

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