multi-drug — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9014	SKI-178		Apoptosis , S1P Receptor
	SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during ...		Apoptosis , S1P Receptor
T15168	DRF-1042		Others
	DRF-1042 acts to inhibit DNA topoisomerase I. DRF-1042 displays perfect anticancer activity against a panel of human cancer cell lines including multi-drug resistance (MDR) phenotype.		Others
T14081	Enmetazobactam	AAI101	Antibacterial
	Enmetazobactam (AAI101) is an extended-spectrum β-lactamase inhibitor for the treatment of multi-drug resistant gram-negative bacterial infections.		Antibacterial
T6018	Zosuquidar trihydrochloride	Zosuquidar (LY335979) 3HCl,RS 33295-198 trihydrochloride,RS 33295-198 (D06387) 3HCl,Zosuquidar 3HCl,LY-335979 trihydrochloride	P-gp
	Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3.		P-gp
TQ0152	Dalfopristin	RP54476	Antibacterial , Antibiotic
	Dalfopristin (RP54476) is a semi-synthetic streptogramin antibiotic. Quinupristin/Dalfopristin (Q/D) is used for the treatment of multi-drug resistant Enterococcus faecium infections.		Antibacterial , Antibiotic
TN2213	Imperialine 3-β-D-glucoside	Sipeimine-3-beta-D-glucoside	Others
	Imperialine 3-β-D-glucoside (Sipeimine-3-beta-D-glucoside) is a natural product. Imperialine 3-β-D-glucoside may exhibit anti-tumor properties against multi-drug resistant tumor cells.		Others
T11427	Antibacterial compound 2		Antifungal
	Antibacterial compound 2 is a potent antimicrobial agent effective against many human veterinary pathogens, inhibiting multi-drug resistant staphylococci, enterococci and streptococci, as well as anaerobic bacteria.		Antifungal
T0331L	Moxifloxacin	Avelox,Moxeza	Others , Antibacterial , Antibiotic
	Moxifloxacin (Avelox) is a fourth-generation fluoroquinolone that has been shown to be effective against Gram-positive, Gram-negative, and atypical strains, as well as multi-drug resistant Streptococcus pneumoniae.		Others , Antibacterial , Antibiotic
T9830	GSK2556286	GSK286	Antibacterial
	GSK2556286 (GSK286) is an orally active inhibitor of Mycobacterium tuberculosis (M. tuberculosis).GSK2556286 inhibits the growth of human macrophages with an IC50 value of 0.07 μM.GSK2556286 is effective against both mul...		Antibacterial
T0391	Linezolid	PNU-100766	MAO , Antibacterial , Antibiotic
	Linezolid (PNU-100766), the first of the oxazolidinone class, is a synthetic antibiotic used for the therapy of infections resulted from multi-resistant bacteria including methicillin-resistant Staphylococcus aureus (MRS...		MAO , Antibacterial , Antibiotic
T1146	Nifedipine	BAY-a-1040,Procardia XL,Procardia,Adalat	CaMK , Potassium Channel , Calcium Channel , Autophagy
	Nifedipine (Procardia) is a dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation ...		CaMK , Potassium Channel , Calcium Channel , Autophagy
T31019	CP 117227	CP117227,CP-117227
	CP 117227 is a multi-drug resistance regulator.
T11116	Duocarmycin MA		Others
	Duocarmycin MA can be used against multi-drug resistant cell lines.Duocarmycin MA is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove.		Others
T11117	Duocarmycin MB		Others
	Duocarmycin MB can be used against multi-drug resistant cell lines. Duocarmycin MB is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove.		Others
T26990	CGI-17341	CGI17341
	CGI-17341 is an orally active representative of the 5-nitroimidazole series of antimicrobial agents. CGI 17341 inhibits the drug-susceptible and multi-drug-resistant strains of Mycobacterium tuberculosis at concentration...
T26733	B 746	B-746,B746
	B 746 is an antibacterial agent primarily. B 746 is used in therapy for leprosy and Mycobacterium avium infections as well as against Mycobacterium tuberculosis, including those with multi-drug resistance.
T11115	Duocarmycin GA		Others
	Duocarmycin GA, an antibody drug conjugate (ADC) toxin and a DNA alkylating agent, effectively targets and binds in the minor groove of DNA. It is particularly potent against multi-drug resistant cell lines, offering a s...		Others
TN1397	Ardisiacrispin B		Others
	Ardisiacrispin B displays cytotoxic effects in multi-factorial drug resistant cancer cells via ferroptotic and apoptotic cell death.		Others
TN2726	Jatrophane 5		P-gp
	Jatrophane 5 demonstrates the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR).		P-gp
T71593	AVN-101 free base
	AVN-101 is a very potent 5-HT7 receptor antagonist, with slightly lesser potency toward 5-HT6, 5-HT2A, and 5HT-2C receptors. It is a multi-target drug candidate for the treatment of CNS disorders.