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Linezolid

Catalog No. T0391   CAS 165800-03-3
Synonyms: PNU-100766

Linezolid (PNU-100766), the first of the oxazolidinone class, is a synthetic antibiotic used for the therapy of infections resulted from multi-resistant bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and streptococcus. The drug takes effect as the inhibitor of the initiation of bacterial protein synthesis.

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Linezolid Chemical Structure
Linezolid, CAS 165800-03-3
Pack Size Availability Price/USD Quantity
10 mg In stock $ 43.00
25 mg In stock $ 77.00
50 mg In stock $ 97.00
100 mg In stock $ 148.00
200 mg In stock $ 185.00
500 mg In stock $ 297.00
1 mL * 10 mM (in DMSO) In stock $ 38.00
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Purity: 100%
Purity: 100%
Purity: 99.99%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Linezolid (PNU-100766), the first of the oxazolidinone class, is a synthetic antibiotic used for the therapy of infections resulted from multi-resistant bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and streptococcus. The drug takes effect as the inhibitor of the initiation of bacterial protein synthesis.
In vivo Linezolid effectively inhibits Escherichia coli lacking cellular transcription-translation mechanisms, with an IC50 value of 1.8 mM. Its mode of action primarily involves suppressing the synthesis of early-stage proteins, representing a novel antimicrobial agent that enhances anti-pathogenic activity. Linezolid inhibits the formation of the initiation complex by the E. coli 70S or 30S ribosomal subunit. Due to variations in testing methods and laboratory conditions, discrepancies in Linezolid's MIC (Minimum Inhibitory Concentration) have been noted, yet it consistently displays a narrow sensitivity range, with MIC values for streptococci, staphylococci, and enterococci between 0.5 mg/L and 4 mg/L. Linezolid induces mutations at the 23S rRNA gene binding site. When added to 7H10 agar medium [oleic acid, albumin, dextrose, and catalase], and diluted to final concentrations ranging from 0.125 μg/mL to 4 μg/mL at 50°C-56°C, Linezolid exhibits excellent in vitro activity (MIC values ≤1 μg/mL) against tested strains, including those resistant to SIRE.
Synonyms PNU-100766
Molecular Weight 337.35
Formula C16H20FN3O4
CAS No. 165800-03-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 8.4 mg/mL (25 mM)

DMSO: 55 mg/mL (163.04 mM)

TargetMolReferences and Literature

1. Swaney SM, et al. Antimicrob Agents Chemother, 1998, 42(12), 3251-3255. 2. Shinabarger DL, et al. Antimicrob Agents Chemother, 1997, 41(10), 2132-2136. 3. Noskin GA, et al. Antimicrob Agents Chemother, 1999, 43(8), 2059-2062. 4. Livermore DM, et al. J Antimicrob Chemother, 2003, 51 Suppl 2, ii9-16. 5. Alcalá L, et al. Antimicrob Agents Chemother, 2003, 47(1), 416-417.

Related compound libraries

This product is contained In the following compound libraries:
Drug Repurposing Compound Library Inhibitor Library Orally Active Compound Library Hematopoietic Toxicity Compound Library Bioactive Compounds Library Max ReFRAME Related Library Anti-Diabetic Compound Library Human Metabolite Library Drug-induced Liver Injury (DILI) Compound Library Anti-COVID-19 Compound Library

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Keywords

Linezolid 165800-03-3 Metabolism Microbiology/Virology Neuroscience MAO Antibiotic Antibacterial PNU-100766 inhibit Inhibitor PNU100766 Bacterial PNU 100766 inhibitor

 

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