ischaemic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7736	2-Chloroadenosine		Adenosine Receptor
	2-Chloroadenosine (CADO) is a metabolically stable analog of adenosine that binds to adenosine A1, A2A, and A3 receptors( Ki:300, 80, and 1,900 nM, respectively)		Adenosine Receptor
T21687	Conoidin A		Parasite
	Conoidin A is a cell permeable inhibitor of T. gondii enzyme peroxiredoxin II (TgPrxII) with nematicidal properties. It covalently binds to the peroxidatic Cys47 of TgPrxII, irreversibly inhibiting its hyperperoxidation ...		Parasite
T1940	BTB06584		RAAS , ATPase
	BTB06584 is an IF1-dependent, selective inhibitor of the mitochondrial F1 Fo-ATPase. BTB06584 is a novel acetohydroxyacid synthase(AHAS) inhibitor, a promising drug target against Mycobacterium tuberculosis (MTB).		RAAS , ATPase
T3268	Mildronate	Kvaterin,Meldonium,Quaterin	Hydroxylase
	Mildronate (Meldonium) is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption.		Hydroxylase
T2535	Ivabradine hydrochloride	S 16257-2,Ivabradine HCl	Adrenergic Receptor
	Ivabradine hydrochloride (S 16257-2) is a new If inhibitor (IC50: 2.9 μM). Ivabradine Hydrochloride is the hydrochloride salt form of ivabradine, an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gat...		Adrenergic Receptor
T15757	Limaprost	17α,20-dimethyl-δ2-PGE1,OP1206,ONO1206	PGE Synthase
	Limaprost (17α,20-dimethyl-δ2-PGE1) is an analog of PGE1 with structural modifications intended to give it a prolonged half-life and greater potency.It is a potent and orally active vasodilator. Limaprost increases blood...		PGE Synthase
TN7089	Alashinol G	(-)-Carinol	Others
	Alashinol G ((-)-Carinol) is isolated from the stem bark of Syringa pinnatifolia, a Mongolian folk medicine with anti-myocardial ischaemic effects.		Others
T20887	Atorvastatin Sodium	Lipitor	LDL , Aquaporin , HMG-CoA Reductase
	Atorvastatin Sodium (Lipitor) is a competitive inhibitor of HMG-CoA reductase and increases the expression of low density lipoprotein (LDL) receptors on hepatocytes. Atorvastatin Sodium treatment inhibits aquaporin 4 to ...		LDL , Aquaporin , HMG-CoA Reductase
T22798	Gavestinel	GV 150526,Gavestinel sodium salt	NMDAR , iGluR
	Gavestinel (GV 150526) is a non-competitive NMDA receptor antagonist that is potent, selective and orally active.Gavestinel binds to the glycine site of the NMDA receptor with a binding affinity (pKi value) of 8.5.Gavest...		NMDAR , iGluR
T26317	VEC6	VEC-6,NSC11435,NSC 11435,NSC-11435,VEC 6
	VEC6 is a VEZF1–DNA interaction inhibitor that recapitulates RhoB loss in ischaemic retinopathy.
T69004	Falipamil hydrochloride
	Falipamil hydrochloride is a calcium channel antagonist potentially for the treatment of ischaemic heart disorder and sinus.
T26875	BN 50739	BN50739,BN-50739
	BN 50739 is an antagonist of platelet-activating factor (PAF). BN 50739 suppresses certain cardiac arrhythmias. PAF is released from ischaemic myocardium and may contribute to initiation of ischaemia-induced ventricular ...
T64205	HAMI 3379
	HAMI 3379 is a potent and selective CysLT2 receptor antagonist. HAMI 3379 exhibits protective effects against acute and subacute ischaemic brain injury and reduces microglia-associated inflammation.
T63014	Ivabradine
	Ivabradine is a potent, orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits pacemaker current (If). ivabradine decreases heart rate in a dose-dependent manner and does no...
T37297	Ru360
	Ru360, an oxygen-bridged dinuclear ruthenium amine complex, is a selective mitochondrial calcium uptake inhibitor. Ru360 potently inhibits Ca2+ uptake into mitochondria with an IC50 of 0.184 nM. Ru360 binds to mitochondr...