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Limaprost

Catalog No. T15757   CAS 74397-12-9
Synonyms: 17α,20-dimethyl-δ2-PGE1, OP1206, ONO1206

Limaprost (17α,20-dimethyl-δ2-PGE1) is an analog of PGE1 with structural modifications intended to give it a prolonged half-life and greater potency.It is a potent and orally active vasodilator. Limaprost increases blood flow and inhibits platelet aggregation. Limaprost (17α,20-dimethyl-δ2-PGE1) can be used for pain relief, has antianginal effects, and has potential for ischaemic symptoms treatment.

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Limaprost Chemical Structure
Limaprost, CAS 74397-12-9
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Purity: 99.89%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Limaprost (17α,20-dimethyl-δ2-PGE1) is an analog of PGE1 with structural modifications intended to give it a prolonged half-life and greater potency.It is a potent and orally active vasodilator. Limaprost increases blood flow and inhibits platelet aggregation. Limaprost (17α,20-dimethyl-δ2-PGE1) can be used for pain relief, has antianginal effects, and has potential for ischaemic symptoms treatment.
In vitro By a concentration-dependent manner, Limaprost inhibits the IL-1-mediated induction of nerve growth factor (IC50: 70.9 ?nM human IVD cells) [3].
In vivo PGE1 and limaprost exhibited a novel pharmacological action that suppresses NGF expression in human IVD cells, and other prostanoids differentially regulated NGF expression.?Limaprost has been used to treat patients with lumbar spinal stenosis in Japan and was proved to be effective in relieving symptoms.Platelet aggregation, adhesiveness, bleeding time, and thrombocytopenia induced by ADP and collagen infusion in guinea-pigs are inhibited by oral administration of Limaprost at the same doses or doses less than those relieving vasopressin-induced ST depression of ECG.?Intra-coronary injection of Limaprost (1-100 ng/kg) in dogs causes a remarkable increase in coronary blood flow without any influence on heart rate, blood pressure, myocardial oxygen consumption, and redox potential.?Limaprost given orally at more than 100 mg/kg relieves vasopressin-induced ST depression of rat electrocardiogram.?Resistance in both large and small vessels of the dog coronary artery is decreased by intravenous injection of Limaprost (1-3 mg/kg) [1].
Synonyms 17α,20-dimethyl-δ2-PGE1, OP1206, ONO1206
Molecular Weight 380.52
Formula C22H36O5
CAS No. 74397-12-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 40 mg/mL (105.12 mM)

TargetMolReferences and Literature

1. Tsuboi T, et al. Pharmacological evaluation of OP 1206, a prostaglandin E1 derivative, as an antianginal agent. Arch Int Pharmacodyn Ther. 1980 Sep;247(1):89-102. 2. Swainston Harrison T, et al. Limaprost. Drugs. 2007;67(1):109-18; discussion 119-20. 3. Murata K, et al. PGE1 Attenuates IL-1β-induced NGF Expression in Human Intervertebral Disc Cells. Spine (Phila Pa 1976). 2016 Jun;41(12):E710-6.

Related compound libraries

This product is contained In the following compound libraries:
NO PAINS Compound Library

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Keywords

Limaprost 74397-12-9 Immunology/Inflammation PGE Synthase platelet ADP Prostaglandin E synthase aggregation inhibit ischaemic Antianginal 17alpha,20-dimethyl-delta2-PGE1 17α,20-dimethyl-δ2-PGE1 ONO 1206 OP-1206 alprostadil PGE1 Inhibitor IL-1 OP 1206 adhesion PGE synthase atherosclerotic OP1206 17a,20-dimethyl-δ2-PGE1 vasodilator ONO-1206 ONO1206 inhibitor

 

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