hearts — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8674	SR33805		Calcium Channel
	SR33805 is a potent antagonist of Ca2+ channel(EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively)		Calcium Channel
T12321	ORM-10103		Calcium Channel
	ORM-10103 is a novel potent and selective inhibitor of the Na+/Ca2+ exchanger (NCX).ORM-10103 inhibited NCX currents with estimated IC50 values of 55 and 67 nM at -80 and 20 mV, respectively, and reduced early and delaye...		Calcium Channel
T60247	Diethylamine NONOate diethylammonium salt	NOC-18 Diethylamine,DEA NONOate diethylamine	Antibiotic
	Diethylamine NONOate diethylammonium salt (DEA NONOate diethylamine) is a nitric oxide donor with antibacterial activity, a dispersant for preformed biofilms of Pseudomonas aeruginosa and inhibits the growth of E. coli. ...		Antibiotic
T20094	Adrenochrome	Adraxone	Antioxidant
	Adrenochrome (Adraxone) is a cytotoxic molecule that can be used to kill bacteria. Adrenochrome is an oxidized product of Epinephrine. Adrenochrome is a coronary systolic compound that acts on rat hearts and is associate...		Antioxidant
T2973	Astragaloside IV	AST-IV,AS-IV	MMP , ERK , Estrogen/progestogen Receptor , JNK
	Astragaloside IV (AS-IV), an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cel...		MMP , ERK , Estrogen/progestogen Receptor , JNK
T4518	Licochalcone D		ERK , NF-κB
	Licochalcone D may be a potential drug for human melanoma treatment by inhibiting proliferation, inducing apoptosis via the mitochondrial pathway and blocking cell migration and invasion. Licochalcone D has cardioprotect...		ERK , NF-κB
T16420	P-1075		Potassium Channel
	P-1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species causing cardioprotection of rabbit hearts. P-1075 is an effective activator of sulfonylurea receptor 2-associated ATP-sensitive potassium c...		Potassium Channel
T13588	Ipramidil	C80-1324	Others
	Ipramidil (C80-1324) reveals marked dilator activity in the coronary circulation of isolated working hearts.		Others
T24145	Hns 32	Hns32,Hns-32
	Hns 32 possesses antiarrhythmic properties in dog and guinea pig hearts. It also has vasodilator action.
T40850	[D-Trp11]-Neurotensin	[D-Trp11]-Neurotensin
	[D-Trp11]-Neurotensin is a compound that functions as a selective antagonist of Neurotensin (NT) in perfused rat hearts, while exhibiting full agonist properties in guinea pig atria and rat stomach strips. Additionally, ...
T26621	AMP-579	RPR100579,RPR 100579,AMP 579,RPR-100579
	AMP-579 is an adenosine A1 receptor agonist. AMP-579 also acts as a A2b-adenosine receptor agonist in human 293 cells and rabbit hearts.
TP1923	Elabela(19-32)	ELA-14 (human)
	Potent apelin (APJ) receptor agonist (Ki = 0.93 nM). Bioactive fragment of ELA-32. Activates Gαi1 pathway and β-arrestin-2 recruitment. Reduces arterial pressure in rat hearts. Active in vivo.
T75953	BeKm-1 TFA
	BeKm-1 TFA is a potent, selective blocker of the KV11.1 (hERG) channel, demonstrating specificity for KV11.1 over 14 other potassium channels. This compound dose-dependently prolongs the QTc interval in isolated rabbit h...
TN1412	Astringin	trans-Astringin	IL Receptor , Others
	Astringinin is a potent antiarrhythmic agent with cardioprotective activity in ischemic and ischemic-reperfused rat heart, the beneficial effects of astringinin in the ischemic and ischemic-reperfused hearts may be corre...		IL Receptor , Others
T35873	C19 Ceramide (d18:1/19:0)	C19 Ceramide (d18:1/19:0)
	C19 Ceramide is a naturally occurring ceramide that has been found in J. juncea extracts as well as rat brain and mouse heart.[1],[2],[3] It is elevated in adult and decreased in juvenile whole rat brain extracts by 114 ...
TN3914	Echinatine		ATPase , IL Receptor , TNF
	Echinatin exerts a protective effect against ischemia/reperfusion (I/R)-induced myocardial injury on hearts, this effect may be attributed to the antioxidant and anti-inflammatory activities of this compound. Echinatin c...		ATPase , IL Receptor , TNF
T68878	L-2286
	L-2286 is a novel PARP inhibitor. L-2286 exerted significant protective effect against ischemia-reperfusion-induced myocardial injury in both experimental models. More importantly, L-2286 facilitated the ischemia-reperfu...
TP2096	ELA-21 (human)
	High affinity apelin receptor agonist. Binds apelin receptors in left ventricle from normal and pulmonary arterial hypertensive (PAH) hearts (pKi values are 9.31 and 9.46, respectively). Bioactive fragment of ELA-32. Inh...
T36561	(3S)-hydroxy Quinidine
	(3S)-hydroxy Quinidine is an active quinidine metabolite. Quinidine, an antiarrhythmic agent, undergoes rapid first-pass metabolism by the cytochrome P450 (CYP) isoforms CYP3A4, CYP2C9, CYP2E1, and CYP3A5, with CYP3A4 be...
T74988	DIBA-Cy5
	DIBA-Cy5, a fluorescent DIBA antagonist, consists of DIBA-alkyne and Cyanine5 fluorophores (Cy5) linked by a polyethylene glycol (PEG) chain. It functions as a fluorescent ligand for probe attachment via click chemistry,...