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Ipramidil

Catalog No. T13588 CAS 83656-38-6

Synonyms: C80-1324

Ipramidil (C80-1324) reveals marked dilator activity in the coronary circulation of isolated working hearts.

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Ipramidil, CAS 83656-38-6

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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Description

Ipramidil (C80-1324) reveals marked dilator activity in the coronary circulation of isolated working hearts.

In vitro

The vasodilator action of Ipramidil on coronary vessels is more potent than that of glyceryl trinitrate (GTN) and appears to be biphasic. The increase in coronary flow caused by furoxans as well as by GTN is blunted upon the confusion of the guanylate cyclase inhibitor methylene blue. NO sign of tachyphylaxis of the vasodilator response is seen upon the repeated or continuous (60 min) application of Ipramidil at a concentration of 1 μg/mL, which induces an increase in the coronary flow of 67±9%. Moreover, the vasodilator effect of Ipramidil is not different from control when Ipramidil is given after a 60 min preinfusion of 10 μg/mL GTN, i.e. under conditions of nitrate tolerance. However, when GTN is applied after a 30 min infusion of Ipramidil, its dilator response is significantly diminished. Unlike GTN, Ipramidil concentration independently increases the spontaneous beating rate of the hearts by 10-30 beats per minute and appeared to have a weak positive inotropic effect.

Synonyms	C80-1324
Molecular Weight	256.26
Formula	C10H16N4O4
CAS No.	83656-38-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Feelisch M, et al. Thiol-mediated generation of nitric oxide accounts for the vasodilator action of furoxans. Biochem Pharmacol. 1992 Sep 25;44(6):1149-57.

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Keywords

Ipramidil 83656-38-6 Others C80-1324 inhibitor inhibit

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