endonuclease-1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T63808	Cap-dependent endonuclease-IN-1		Others
	Cap-dependent endonuclease-IN-1 is a highly potent and orally active cap-dependent endonuclease inhibitor with antiviral activity for the study of influenza virus infection.		Others
T8545	FEN1-IN-4	FEN1 Inhibitor C2	Others
	FEN1-IN-4 (FEN1 Inhibitor C2) is an inhibitor of human flap endonuclease-1 (hFEN1)		Others
T15507	Hycanthone	Etrenol(mesylate),Win 249-33	DNA/RNA Synthesis , Topoisomerase , Parasite
	Hycanthone (Etrenol(mesylate)) is a potent drug of antischistosomal. Hycanthone is a DNA intercalator that inhibits RNA synthesis and DNA topoisomerases I and II. Hycanthone inhibits nucleic acid biosynthesis and inhibit...		DNA/RNA Synthesis , Topoisomerase , Parasite
T60379	PUL89 Endonuclease-IN-1
	pUL89 Endonuclease-IN-1 (Compound 13d), with an IC50 value of 0.88 μM, serves as a potent inhibitor of human cytomegalovirus (HCMV) pUL89 endonuclease, demonstrating antiviral activity [1].
T6823	E3330		HIF/HIF Prolyl-Hydroxylase , DNA/RNA Synthesis
	E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.		HIF/HIF Prolyl-Hydroxylase , DNA/RNA Synthesis
T4569	Lucanthone	Lucantona,Lucanthonum	DNA/RNA Synthesis , Autophagy
	Lucanthone (Lucanthonum) is an inhibitor of Apurinic endonuclease-1 (APE-1).		DNA/RNA Synthesis , Autophagy
T66154	Paroxypropione
	It is an inhibitor of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1)
T9743	FEN1-IN-SC13		Others
	FEN1-IN-SC13 is a potent inhibitor of DNA fragmentation endonuclease 1 (FEN1)		Others
T9147	FEN1-IN-3
	FEN1-IN-3 is a human flap endonuclease-1 ( hFEN1 ) inhibitor that stabilizes hFEN1 with an EC 50 of 6.8 μM .
T15274	FEN1-IN-1	LNT-1	Others
	FEN1-IN-1 (LNT-1) is an inhibitor of flap endonuclease 1 (FEN1). FEN1-IN-1 binds to the active site of FEN1. It partly achieves inhibition by the co-ordination of Mg2+ ions.		Others
T60904	ERCC1-XPF-IN-2		Others
	ERCC1-XPF-IN-2 is active in nucleotide excision repair, cisplatin enhancement and γH2AX assays. ERCC1-XPF-IN-2 is a potent inhibitor of ERCC1-XPF endonuclease with an IC 50 value of 0.6 μM [1].		Others
T61487	APE1-IN-1		DNA/RNA Synthesis
	APE1-IN-1 is a potent purine/pyrimidine endonuclease 1 (APE1)-free inhibitor that crosses the blood-brain barrier with potential antitumor activity and potentiates the cytotoxicity of the alkylating agent, methyl methane...		DNA/RNA Synthesis
T74295	Cap-dependent endonuclease-IN-22
	Cap-dependent endonuclease-IN-22 is a powerful inhibitor of cap-dependent endonuclease (CEN) [1].
T61840	PUL89 Endonuclease-IN-2
	pUL89 Endonuclease-IN-2 (Compound 15k) is a highly effective inhibitor of the pUL89 endonuclease of human cytomegalovirus (HCMV). With an IC50 of 3.0 μM, it exhibits potent antiviral activities [1].
T69128	NSC-13755
	NSC-13755 is a human flap endonuclease 1 (FEN1) inhibitor.
T61757	Cap-dependent endonuclease-IN-26
	Cap-dependent endonuclease-IN-26, a potent inhibitor of cap-dependent endonuclease (CEN) with an IC50 of 286 nM, exhibits significant antiviral activity against a broad spectrum of influenza A and B strains [1].
T74294	Cap-dependent endonuclease-IN-12
	Cap-dependent Endonuclease-IN-12 (EXP-35) is a potent inhibitor of Cap-dependent endonuclease, demonstrating low cytotoxicity. This compound exhibits inhibitory effects on H1N1 [1].
T68449	JFD00950
	JFD00950 is a human flap endonuclease 1 (FEN1) inhibitor with in vitro inhibition of flap cleavage activity as well as cytotoxic activity against a colon cancer cell line, DLD-1.
T79134	FEN1-IN-6		FLAP
	FEN1-IN-6 (compound 9) is a potent Flap endonuclease-1 (FEN1, IC50 = 10 nM) inhibitor, crucial for DNA damage repair in mammalian cells, and additionally targets the related endonuclease xeroderma pigmentosum G (XPG) wit...		FLAP
T78192	FEN1-IN-5		FLAP
	FEN1-IN-5 (compound 12A) is a potent Flap endonuclease-1 (FEN1) inhibitor with an IC50 value of 12 nM, playing a role in DNA repair mechanisms [1].		FLAP