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Lucanthone

Catalog No. T4569 CAS 479-50-5

Synonyms: Lucantona, Lucanthonum

Lucanthone (Lucanthonum) is an inhibitor of Apurinic endonuclease-1 (APE-1).

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Lucanthone, CAS 479-50-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 51.00
2 mg	In stock	$ 73.00
5 mg	In stock	$ 128.00
10 mg	In stock	$ 198.00
25 mg	In stock	$ 422.00
50 mg	In stock	$ 623.00
100 mg	In stock	$ 882.00
1 mL * 10 mM (in DMSO)	In stock	$ 143.00

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Purity: 99.76%

Biological Description

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Description	Lucanthone (Lucanthonum) is an inhibitor of Apurinic endonuclease-1 (APE-1).
In vitro	Lucanthone, an innovative autophagy inhibitor, induces apoptosis through cathepsin D activation and has been evaluated for its anticancer efficacy via MTT assay. Demonstrating a consistent reduction in viability across seven breast cancer cell lines, Lucanthone surpasses Chloroquine (CQ) in potency, evidenced by a significantly lower mean IC50 of 7.2 μM compared to 66 μM for CQ. Further validation through ATPlite assay and trypan blue exclusion in two representative cell lines (MDA-MB-231 and BT-20) confirms these findings.
Cell Research	Cell viability is assessed by MTT assay. Cells are seeded into 96-well microculture plates at 10,000 cells per well and allowed to attach for 24 h. Cells are then treated with Lucanthone (0, 0.5, 1, 5, 10, 20 and 40 μM), Chloroquine, Vorinostat, or combinations for 72 h. Following drug treatment, MTT is added and cell viability is quantified using a BioTek microplate reader. Effects on cell viability are also determined by measuring ATP levels using the ATPlite assay system and by trypan blue exclusion. Pro-apoptotic effects following in vitro drug exposure are quantified by propidium iodide (PI) staining and fluorescence-activated cell sorting (FACS) analysis of sub-G0/G1 DNA content[2]

Synonyms	Lucantona, Lucanthonum
Molecular Weight	340.48
Formula	C20H24N2OS
CAS No.	479-50-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (176.22 mM), Sonication is recommended.

References and Literature

1. Chowdhury SM,etal.Graphene nanoribbons as a drug delivery agent for lucanthone mediated therapy of glioblastoma multiforme.Nanomedicine. 2015 Jan;11(1):109-18. 2. Carew JS,etal.Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis.J Biol Chem. 2011 Feb 25;286(8):6602-13.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Drug Library Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Target-Focused Phenotypic Screening Library Clinical Compound Library ReFRAME Related Library Bioactive Compound Library Anti-Aging Compound Library

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Keywords

Lucanthone 479-50-5 Autophagy Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis Lucantona inhibit Lucanthonum Inhibitor inhibitor

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