eif2α — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T62637	EIF2α activator 2
	EIF2α activator 2 (Compound 1) is a phosphorylated activator of eukaryotic initiation factor 2α (eIF2α). EIF2α activator 2 is anti-proliferative in K562 cells (IC50: 4.79 μM) and PBMC cells (IC50: 10.52 μM).
T63665	EIF2α activator 1
	EIF2α Activator 1 (Compound 40) is a chemical compound that activates the phosphorylation of eukaryotic initiation factor 2 alpha (eIF2α), enhancing the expression of downstream proteins ATF and CHOP. It demonstrates ant...
T9174	Icerguastat	Sephin 1,lcerguastat,IFB-088	Phosphatase
	Icerguastat (IFB-088) is a selective inhibitor of holophosphatase. Sephin1 safely and selectively inhibited a regulatory subunit of protein phosphatase 1 in vivo.		Phosphatase
T19459	N1-Methylpseudouridine	1-Methylpseudouridine	Others
	N1-Methylpseudouridine (1-Methylpseudouridine) is a methylpseudouridine and enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density in mRNA.		Others
T7150	BTdCPU		Apoptosis , Phosphatase , PERK
	BTdCPU is a potent activator of heme-regulated eIF2α kinase (HRI) . BTdCPU promotes eIF2α phosphorylation and induced apoptosis in resistant cell.		Apoptosis , Phosphatase , PERK
T3045	Salubrinal		Apoptosis , Phosphatase , PERK , Autophagy , HSV
	Salubrinal, a phosphatases (PP1) inhibitor(IC50=1.7 μM), exhibits function on the eukaryotic translation initiation factor 2 subunit (eIF2α).		Apoptosis , Phosphatase , PERK , Autophagy , HSV
T2417	Sal003		Apoptosis , Phosphatase , PERK
	Sal003, an effective cell-permeable analog, inhibitis the eIF2α phosphatase.		Apoptosis , Phosphatase , PERK
T11374	GCN2-IN-6		Others , PERK
	GCN2-IN-6 is also a eIF2α kinase PERK inhibitor with an IC50 of 0.26 nM (in enzymatic assay) and 230 nM (in cells). GCN2-IN-6 is a potent, and orally available GCN2 inhibitor confirmed by in-house enzymatic (IC50 of 1.8...		Others , PERK
T21824	Sephin1	NSC 65390,IFB-088	Phosphatase
	Sephin1 (IFB-088) is reportedly a selective inhibitor of GADD34 (PPP1R15A), which is a stress-induced regulatory subunit of protein phosphatase 1 complex that dephosphorylates eIF2α		Phosphatase
T6854	GSK621		Apoptosis , AMPK , Autophagy
	GSK621 is a specific and potent AMPK activator.		Apoptosis , AMPK , Autophagy
T6183	ISRIB (trans-isomer)	ISRIB,ISRIB trans-isomer,trans-isomer,trans-ISRIB	Apoptosis , PERK , Autophagy
	ISRIB (trans-isomer) (ISRIB trans-isomer), the trans-isomer of ISRIB, is a effective and specific PERK inhibitor (IC50: 5 nM).		Apoptosis , PERK , Autophagy
T69440	Sephin1 Hydrochloride
	Sephin1 hydrochloride is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A), which prolongs the benefit of eIF2α phosphorylation, thereby protecting cells from proteostatic defects.
T69106	Avarol
	Avarol induces apoptosis in pancreatic ductal adenocarcinoma cells by activating PERK-eIF2α-CHOP signaling. Avarl also acts as a competitive AChE inhibitor which are non-hepatotoxic and neuroprotective agents for Alzheim...
T63008	PERK-IN-5
	PERK-IN-5 is a highly selective, potent, orally active inhibitor of the protein kinase R-like endoplasmic reticulum (ER) kinase (PERK) that acts on PERK (IC50: 2 nM) and p-eIF2α (IC50: 9 nM). PERK-IN-5 significantly inhi...
T78875	BTM-3528		Mitochondrial Metabolism
	BTM-3528 is a mitochondrial protease OMA1 activator that induces an overactivation of the mitochondrial integrated stress response (ISR). It promotes OMA1-dependent cleavage of DELE1 and OPA1, leading to mitochondrial fr...		Mitochondrial Metabolism