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GSK621

Catalog No. T6854 CAS 1346607-05-3

GSK621 is a specific and potent AMPK activator.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

GSK621, CAS 1346607-05-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 50.00
5 mg	In stock	$ 109.00
10 mg	In stock	$ 189.00
25 mg	In stock	$ 372.00
50 mg	In stock	$ 549.00
100 mg	In stock	$ 783.00

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Purity: 99.01%

Purity: 98.44%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	GSK621 is a specific and potent AMPK activator.
In vitro	In AML cell lines and primary AML samples, GSK621 markedly increases phosphorylation at AMPKα T172, a marker of AMPK activation. In a set of 20 cell lines, GSK621 reduces the proliferation of all 20 lines with IC50 ranged from 13-30 μM, and increases apoptosis in 17 (85%) lines. In addition, GSK621 also triggers autophagy, which partially contributes to AML cell death. [1]
In vivo	In nude mice bearing MOLM-14 xenografts, GSK621 (30 mg/kg, i.p.) reduces leukemia growth and significantly extends survival by enhancing AMPK activity and the induction of apoptosis. [1]
Kinase Assay	AMPK enzymatic assay: HEPG2 cells are treated with increasing doses of A-769662 or GSK621, and ACC S79 phosphorylation is assessed as a surrogate marker for AMPK activation using a commercially available ELISA kit.
Cell Research	Twenty AML cell lines are treated with log10 dilutions of GSK621 and relative viability is determined by CellTiter-Glo?assay. IC50 of GSK621 among these 20 cell lines is calculated using the Prism software and are presented as log[C] with [C] in mol/l (M). Results are presented for 5 different cell lines per panel.(Only for Reference)

Molecular Weight	489.91
Formula	C26H20ClN3O5
CAS No.	1346607-05-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90 mg/mL (183.7 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Sujobert P, et al. Cell Rep. 2015, 11(9), 1446-1457.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Bioactive Compounds Library Max Anti-Cancer Metabolism Compound Library Glutamine Metabolism Compound Library Anti-Pancreatic Cancer Compound Library Lipid Metabolism Compound Library Anti-Prostate Cancer Compound Library Oxidation-Reduction Compound Library Glycolysis Compound Library Anti-Aging Compound Library

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Keywords

GSK621 1346607-05-3 Apoptosis Autophagy Chromatin/Epigenetic PI3K/Akt/mTOR signaling AMPK CHOP inhibit AMP-activated protein kinase Inhibitor GSK-621 UPR PERK ATF4 GSK 621 ER Stress inhibitor

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