cyclin — TargetMol Chemicals

Cat No.	Product Name	Targets
TP2192	Cdk2/Cyclin Inhibitory Peptide I	Others
	Cyclin-dependent kinase 2 also known as cell division protein kinase 2. The protein encoded by this gene is a member of the cyclin-dependent kinase family of Ser/Thr protein kinases. This protein kinase is highly similar...	Others
T76377	Cdk2/Cyclin Inhibitory Peptide II
	Cdk2/Cyclin Inhibitory Peptide II (Tat-LDL), a CDK2 inhibitor, demonstrates dose-dependent cytotoxic effects on U2OS osteosarcoma cells [1].
T82758	CDK9-Cyclin T1 PPI-IN-1	CDK
	CDK9-Cyclin T1 PPI-IN-1 (Compound B19) is a selective inhibitor of the CDK9-Cyclin T1 protein-protein interaction (PPI), suppressing cell proliferation in TNBC MDA-MB-231 cells with an IC50 of 0.044 μM and inducing apopt...	CDK
T2029	Bohemine	ERK , CDK
	Bohemine is a cyclin-dependent kinase inhibitor.	ERK , CDK
T7426	ALSTERPAULLONE	Apoptosis , GSK-3 , CDK
	Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec	Apoptosis , GSK-3 , CDK
T60025	Eciruciclib	CDK
	Eciruciclib is an inhibitor of CDK with antitumor properties.	CDK
T39957	CDK4/6-IN-6	CDK
	CDK4/6-IN-6 is a potent CDK4/CDK6 inhibitor with Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.	CDK
T5673	Senexin A	CDK
	Senexin A is an effective and selective CDK8 inhibitor that also inhibits CDK19 with Kd values of 0.83 microns and 0.31 microns, respectively.	CDK
T9849	HQ461	CDK , Molecular Glues
	HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.	CDK , Molecular Glues
T7789	DRB	HIV Protease
	DRB is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II (IC50 range of 4-10 μM)	HIV Protease
T2356	Ro-3306	Apoptosis , ERK , SGK , PKA , CDK , PKC
	RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinases.	Apoptosis , ERK , SGK , PKA , CDK , PKC
T5395	BSJ-03-123	CDK
	BSJ-03-123 is a potent, CDK6-selective small-molecule degrader.	CDK
T5358	Longdaysin	ERK , Casein Kinase , CDK
	Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 µM). It also can inhibit ERK2 (IC50: 52 µM).	ERK , Casein Kinase , CDK
T5S1467	Cucurbitacin E	CDK , Autophagy
	Cucurbitacin E is a natural product isolated from the climbing stem of Cucumic melo L. It significantly suppresses the activity of the cyclin B1/CDC2 complex.Cucurbitacin E has prevention of neurodegeneration, it has pot...	CDK , Autophagy
T4482	CC-671	Others , CDK
	CC-671 is a dual TTK protein kinase (IC50: 0.005 μM) /CLK2 (IC50: 0.006 μM) inhibitor.	Others , CDK
T10436	AZD4573	CDK
	AZD4573 is an effective and selective CDK9 inhibitor (IC50: <4 nM). It enables transient target engagement for the treatment of hematologic malignancies.	CDK
T14901	CCT-251921	CDK
	CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor (IC50: 2.3 nM).	CDK
T8801	SRI-29329	CDK
	SRI-29329 is a potent, specific inhibitor of CDC-like kinase (with IC50 of 78 nM, 16 nM and 86 nM for CLK1, CLK2 and CLK4, respectively).	CDK
T8484	JSH-150	CDK
	JSH-150 is a highly selective CDK9 inhibitor(IC50 : 1 nM).	CDK
T16391	ON-013100	CDK
	ON-013100 is an antineoplastic drug. ON-013100 also acts as a mitotic inhibitor that could inhibit Cyclin D1 expression.	CDK