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Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BSJ-03-123 is a potent, CDK6-selective small-molecule degrader.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 84.00 | |
2 mg | In stock | $ 122.00 | |
5 mg | In stock | $ 197.00 | |
10 mg | In stock | $ 288.00 | |
25 mg | In stock | $ 455.00 | |
50 mg | In stock | $ 622.00 | |
100 mg | In stock | $ 888.00 | |
500 mg | In stock | $ 1,790.00 |
Description | BSJ-03-123 is a potent, CDK6-selective small-molecule degrader. |
In vitro | BSJ-03-123 induced rapid, dose-dependent ternary complex formation with CDK6 and CRBN, but not with CDK4 and CRBN. Ternary complex formation was prevented by blocking binding sites on CDK6 or CRBN via pretreatment with palbo or lenalidomide. |
Cell Research | 4x10^6 MV4-11 CRBN-/- cells were treated for 3 h with 20 μM palbociclib, BSJ-03-123 or vehicle. 1x10^6 cells were spun down at 500 x g for 5 min, and the supernatant removed. Pellets were incubated at 46, 49, 52 or 55°C for 3 min followed by 3 min incubation at room temperature. 30 μl of lysis buffer (20 mM Tris-HCl pH 8.0, 120 mM NaCl, 0.5% NP-40, protease inhibitors) were added and cells lysed by 3 rounds of snap freezing and thawing. Denatured proteins were removed by 20 min centrifugation at 14.000 x g at 4°C and supernatants analyzed by Western Blotting. |
Molecular Weight | 937.01 |
Formula | C47H56N10O11 |
CAS No. | 2361493-16-3 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 115 mg/mL (122.73 mM)
H2O: Insoluble
You can also refer to dose conversion for different animals. More
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BSJ-03-123 2361493-16-3 Cell Cycle/Checkpoint CDK Inhibitor PROTACs Cyclin dependent kinase inhibit BSJ03123 BSJ 03 123 inhibitor