biased — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T28073	MLS1547	MLS000051547,MLS 1547,MLS-1547	Dopamine Receptor
	MLS1547 (MLS000051547) is a highly efficacious agonist of G protein-biased dopamine D2 receptor with a Ki of 1.2 μM. MLS1547 stimulates D2R G protein-mediated signaling with EC50 of 0.37 μM in a calcium mobilization assa...		Dopamine Receptor
T23002	ML-335		Opioid Receptor
	ML-335 is a μ-δ isomer-targeted agonist, a μOR-δOR-biased ligand that can serve as a scaffold for the development of unique types of (isomer-biased) drugs.ML-335 is a MOR (μ-opioid receptor)/DOR (δ-opioid receptor) heter...		Opioid Receptor
T9596	AP1189 acetate		Melanocortin Receptor
	AP1189 acetate is a biased agonist at melanocortin 1 and melanocortin 3 receptors.		Melanocortin Receptor
T7281	F-15599		5-HT Receptor
	F-15599 is a highly selective G-protein biased 5-HT1A receptor agonist(Ki : 3.4 nM).		5-HT Receptor
T40508L	TRV120056 acetate	TRV120056 acetate (40678-47-5 Free base)	Others
	TRV120056 acetate is a Gq-biased agonist with 10-fold greater molecular efficiency on AT1R-Gq fusion proteins than AT1R-βarr2 fusion proteins.		Others
TP2158L1	TRV-120027 acetate (1234510-46-3 free base)		RAAS , Arrestin
	TRV-120027 acetate is a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1 receptor) and engages -arrestins while blocking G-protein signaling.		RAAS , Arrestin
T16321	NI-42		Epigenetic Reader Domain
	NI-42 is a structurally orthogonal chemical probe for the BRPFs and is biased. It effective inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; Kds of BRPF1/2/3=40/210/940 nM). It also has excellent sele...		Epigenetic Reader Domain
TP2158	TRV-120027 TFA	TRV-120027 TFA (1234510-46-3 free base)	RAAS , Arrestin
	TRV120027 TFA is a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R) and engages ß-arrestins while blocking G-protein signaling.		RAAS , Arrestin
T71946	ID110460003
	ID110460003 is a novel μ,δ-Opioid Receptor Dual-Biased Agonist, Overcoming the Limitation of Prior Biased Agonist.
T29064	UNC9975	UNC-9975
	UNC9975 is an analog of aripiprazole and a β-arrestin-biased D2R agonist.
T71438	ID110460001
	ID110460001 is a novel μ,δ-Opioid Receptor Dual-Biased Agonist, Overcoming the Limitation of Prior Biased Agonist.
T71985	ID110460002
	ID110460002 is a novel μ,δ-Opioid Receptor Dual-Biased Agonist, Overcoming the Limitation of Prior Biased Agonist.
T70040	BRD5814
	BRD5814 is a highly brain penetrant β-arrestin biased D2R antagonist.
T40220	TRV055	TRV055
	TRV055 is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV055 is efficacious in stimulating cellular Gq-mediated signaling. TRV055 can be used to develop the Gq-biased AT1R agonists.
T29061	UNC0006	UNC 0006,UNC-0006
	UNC0006 is a β-arrestin-biased dopamine D2 ligand.
T70765	TRV0109101
	TRV0109101 is a G protein-biased agonist of the µ-opioid receptor.
T29066	UNC9995	UNC-9995,UNC 9995
	UNC9995 is a β-Arrestin-Biased Dopamine D2 Receptor agonist (β-Arrestin, EC50 = 120 nM; Emax = 88%).
T69844	NLX-219
	NLX-219 is a selective 5-HT1A receptor-biased agonists.
T40920	TRV056	TRV056
	TRV056 is a Gq-biased agonist of the angiotensin II type 1 receptor (AT1R), demonstrating efficacy in stimulating Gq-mediated cellular signaling. It can serve as a foundation for the development of Gq-biased AT1R agonist...
T29065	UNC9994	UNC-9994,UNC 9994
	UNC9994 is a β-arrestin-biased dopamine D₂ receptor agonist (β-arrestin EC50 = 50 nM; Emax = 97%) with robust in vivo antipsychotic drug-like activities.