keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TRV-120027 acetate is a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1 receptor) and engages -arrestins while blocking G-protein signaling.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 100.00 | |
5 mg | In stock | $ 223.00 | |
10 mg | In stock | $ 398.00 | |
25 mg | In stock | $ 665.00 | |
50 mg | In stock | $ 947.00 | |
100 mg | In stock | $ 1,280.00 | |
500 mg | In stock | $ 2,570.00 |
Description | TRV-120027 acetate is a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1 receptor) and engages -arrestins while blocking G-protein signaling. |
In vitro | TRV120027 TFA (100 nM) induces an [Ca2+]i increase in HEK293 cells co-transfected with AT1R, β-arrestin-1, and TRPC3, which are significantly blocked by Pyr3 pre-incubation in HEK293 cells co-transfected with Flag-AT1R-Cherry, HA-β-arrestin-1, and TRPC3-GFP. TRV120027 TFA (100 nM) significantly increases the AT1R and TRPC3 association with the immunoprecipitated β-arrestin-1 in HEK293 cells co-transfected with Flag-AT1R-cherry, TRPC3-GFP, and HA-β-arrestin-1 [2]. |
In vivo | TRV120027 TFA (i.v.; 0.3 or 1.5 μg/kg per minute; infusion rate, 0.5 mL/min), when added to furosemide, decreases cardiac preload and afterload, systemic and renal vascular resistance, and left ventricular external work while increasing cardiac output and renal blood flow [1]. |
Molecular Weight | 986.14 |
Formula | C45H71N13O12 |
CAS No. | 1824712-70-0 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
TRV-120027 acetate (1234510-46-3 free base) 1824712-70-0 Endocrinology/Hormones GPCR/G Protein RAAS Arrestin TRV120027 acetate (1234510463 free base) 1234510-46-3 free base 1234510-46-3 TRV 120027 acetate (1234510 46 3 free base) TRV120027 Acetate TRV 120027 Acetate TRV-120027 Acetate inhibitor inhibit