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NI-42

Catalog No. T16321 CAS 1884640-99-6

NI-42 is a structurally orthogonal chemical probe for the BRPFs and is biased. It effective inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; Kds of BRPF1/2/3=40/210/940 nM). It also has excellent selectivity over nonclass IV BRD proteins.

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NI-42, CAS 1884640-99-6

Pack Size	Availability	Price/USD
2 mg	In stock	$ 39.00
5 mg	In stock	$ 64.00
10 mg	In stock	$ 105.00
25 mg	In stock	$ 213.00
50 mg	In stock	$ 328.00
100 mg	In stock	$ 513.00
1 mL * 10 mM (in DMSO)	In stock	$ 70.00

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Purity: 99.17%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	NI-42 is a structurally orthogonal chemical probe for the BRPFs and is biased. It effective inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; Kds of BRPF1/2/3=40/210/940 nM). It also has excellent selectivity over nonclass IV BRD proteins.
Targets&IC50	BRD7:82 nM, BRPF3:260 nM, BRPF3:940 nM (kd), BRPF2:210 nM (kd), BRPF2:48 nM, BRPF1:40 nM (kd), BRPF1:7.9 nM, BRD9:1130 nM (kd), BRD9:310 nM, BRD4 BD1:4500 nM
In vitro	NI-42 displays IC50s of 82, 310, and 4500 nM for BRD7, BRD9, and BRD4 (BD1), respectively. It has a Kd of 1130 nM for BRD9.

Molecular Weight	353.39
Formula	C18H15N3O3S
CAS No.	1884640-99-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 95 mg/mL (268.82mM)

References and Literature

1. Igoe N, et al. Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies. J Med Chem. 2017 Jan 26;60(2):668-680.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Reprogramming Compound Library Epigenetics Compound Library NO PAINS Compound Library Histone Modification Compound Library Bioactive Compounds Library Max PPI Inhibitor Library Target-Focused Phenotypic Screening Library Bioactive Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

NI-42 1884640-99-6 Chromatin/Epigenetic Epigenetic Reader Domain Inhibitor inhibit NI 42 NI42 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.