atrophy — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9127	MYLS22		Others
	MYLS22 is a first-in-class and selective inhibitor of optic atrophy 1 (OPA1) . MYLS22 can target endothelial OPA1 to curtail tumor growth and inhibits angiogenesis by impinging on NFkB activity and on angiogenic gene exp...		Others
T8242	Sabinene		Others
	Sabinene is a natural product that has antifungal and anti-inflammatory properties		Others
T1536	Promestriene	3-propyl ethyl,17B-methyl estradiol,Promestriano	Estrogen/progestogen Receptor
	Promestriene (3-propyl ethyl) (INN) is a synthetic estrogen and glucocorticoid used topically in a 1% cream formulation. It is described as a tropic agent and antiseborrheic.		Estrogen/progestogen Receptor
T4641	Branaplam	LMI 070,NVS-SM1	Others , Potassium Channel , DNA/RNA Synthesis
	Branaplam (LMI 070) is a highly potent, selective and orally active small molecule SMN2 splicing modulator.		Others , Potassium Channel , DNA/RNA Synthesis
T16545	Pivanex	Pivalyloxymethyl butyrate,AN-9	Apoptosis , HDAC , Bcr-Abl
	Pivanex (Pivalyloxymethyl butyrate) is an orally active HDAC inhibitor and an antimetastatic and antiangiogenic agent. Pivanex downregulates the Bcr-Abl protein and enhances apoptosis.		Apoptosis , HDAC , Bcr-Abl
T27322	Fispemifene	HM-101,HM 101,HM101	Others
	Fispemifene (HM-101) is an estrogen receptor modulator (SERM) used to treat genitourinary syndromes and vaginal atrophy.		Others
T20802	Flumethasone pivalate	Locacorten,NSC-107680,Lorinden,NSC 107680,NSC107680,Locorten	Others
	Flumethasone pivalate (Locorten) has antipruritic, anti-inflammatory, and vasoconstrictive properties and can be used in studies about adrenocortical suppression, cutaneous atrophy, plasma transcortin binding, and telang...		Others
T3336	Rg3039	PF-06687859	Others
	Rg3039 (PF-06687859) is a potent DcpS inhibitor. DcpS is a therapeutic target for spinal muscular atrophy. Spinal muscular atrophy (SMA) is caused by deletion or mutation of both copies of the SMN1 gene which produces an...		Others
T12935	SMN-C3	MV8T2MCK57	DNA/RNA Synthesis
	SMN-C3 (MV8T2MCK57) is an orally active modulator of SMN2 splicing, and has the potential to treat spinal muscular atrophy (SMA).		DNA/RNA Synthesis
T12718L	RG7800	RO6885247	Others , DNA/RNA Synthesis
	RG7800 (RO6885247) has the potential for spinal muscular atrophy treatment. RG7800 is an SMN2 splicing modifier.		Others , DNA/RNA Synthesis
TP2373L	Biotinoyl tripeptide-1 Acetate	Biotinoyl tripeptide-1 Acetate(299157-54-3 Free base)	Others
	Biotinoyl tripeptide-1 Acetate can produce hair follicles by promoting scalp micro-circulation and reduce follicle atrophy and aging.		Others
T77445	Apitegromab	SRK-015	Opioid Receptor
	Apitegromab (SRK-015) is a new myostatin inhibitor, an antibody targeting myostatin precursor, which can be used to study neuromuscular diseases including spinal muscular atrophy.		Opioid Receptor
T28273L	OT-551 HCl	OT-551 HCl（627085-11-4 Free base）	NF-κB
	OT-551 HCl is an NF-Κb inhibitor, a disubstituted hydroxylamine with antioxidant properties can be used for the treatment of cataracts and age-related macular degeneration and geographic atrophy (GA).		NF-κB
T73475	SMN-C2		DNA/RNA Synthesis
	SMN-C2 is a selective regulator of SMN2 gene splicing, a risdiplam analogue, a selective RNA-binding ligand that regulates pre-mRNA splicing and acts by binding to SMN2 pre-mRNA.SMN-C2 has the potential to be used in the...		DNA/RNA Synthesis
T6620	Ospemifene	FC-1271a	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Ospemifene (FC-1271a) is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. FDA ap...		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
T4592	TOMATIDINE HYDROCHLORIDE	Tomatidine,Tomatidine HCl	Others , NF-κB , JNK , Autophagy
	Tomatidine hydrochloride (Tomatidine HCl) is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway. May be used as a negative control for Cyclopamine and KAAD-Cyclopamine. Tomatid...		Others , NF-κB , JNK , Autophagy
T5294	(S)-Leucic acid	L-LEUCIC ACID,Hydroxyisocaproic acid,(S)-(−)-2-Hydroxyisocaproic acid	Others , Endogenous Metabolite
	(S)-Leucic acid (Hydroxyisocaproic acid) is an end product of leucine metabolism in human tissues such as muscle and connective tissue. It belongs to 2-hydroxycarboxylic acid group of amino acid metabolites. (S)-Leucic a...		Others , Endogenous Metabolite
T33433	MK-3984	MK3984
	Mk-3984 is a selective androgen receptor modulator, which can be used to prevent and treat cancer-related muscle atrophy.
T31168	D153249	D 153249,D-153249
	D153249 is a promoter of spinal muscular atrophy (SMA).
TP2373	Biotinoyl tripeptide-1	Biotin GHK,BiotinGHK,Biotin-GHK
	Biotinoyl tripeptide-1 can produce hair follicles by promoting scalp micro-circulation and reduce follicle atrophy and aging.