tnf-r — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4637	R-7050	TNF-α Antagonist III	TNF
	R-7050 (TNF-α Antagonist III), a tumor necrosis factor receptor (TNFR) antagonist, exhibits heightened selectivity for TNFα.		TNF
T3185	R112	(E)-Elafibranor	Syk
	R112 ((E)-Elafibranor) is an ATP-competitive inhibitor of Syk kinase.		Syk
T6927	Pamapimod	R1503,Ro4402257	p38 MAPK , Autophagy
	Pamapimod (R1503) (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase. It inhibits p38α and p38β enzymatic activity with IC50 values of 0.014±0.002 and 0.48± 0.04 microM, respectiv...		p38 MAPK , Autophagy
TQ0181	Resatorvid	CLI-095,TAK-242	TNF , TLR , Autophagy , Interleukin
	Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor 4 (TLR4). Resatorvid binds directly to Cys747 and prevents TLR4 from binding to TIRAP, thereby blocking downstream signaling. Resatorvid has antitumor a...		TNF , TLR , Autophagy , Interleukin
TN6967	(R)-Isomucronulatol	(-)-Isomucronulatol,2H-1-Benzopyran-7-ol	Apoptosis
	(R)-Isomucronulatol (2H-1-Benzopyran-7-ol), a flavonoid that can be extracted from the leaves of Astragalus membranaceus, Sophora japonica, Sclerotium tigrinum, and Glycyrrhiza glabra, inhibits the proliferation and apop...		Apoptosis
T9645	CU-115	N-(4-(3,5-bis(trifluoromethyl)phenoxy)phenyl)-2-fluoro-6-iodobenzamide	TLR
	CU-115 is a selective and potent TLR8 antagonist with IC50 of 1.04 µM and =>50 µM for TLR8 and TLR7, respectively. CU-115 decreases production of TNF-α and IL-1β activated by R-848 in THP-1 cells.		TLR
T60657	(R)-STU104		TNF , MAPK
	(R)-STU104 is a novel TAK1-MKK3 protein-protein interaction (PPI) inhibitor that inhibits TNF-α and suppresses the TAK1/MKK3/p38/MnK1/MK2/elF4E signalling pathway by binding to MKK3 and disrupting TAK1 phosphorylation of...		TNF , MAPK
T3893	Forsythoside B		TNF , NF-κB
	Forsythoside B binds to LPS and reduces the biological activity of serum LPS, and inhibits NF-κB activation. Forsythoside B inhibits the inflammatory response and has antioxidant properties. Potent neuroprotective effect...		TNF , NF-κB
T38339	R-8507
	R-8507 is a small molecule antagonist of the TNF-α type 1 receptor (TNF-αRI). It inhibits the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-α and IL-1β with EC50 values of 2.45 and 3.79 μM, resp...
T68620	(R)-DOI hydrochloride
	(R)-DOI hydrochloride is a 5-HT2 receptor agonist, inhibiting TNF-α-mediated proinflammatory signaling cascades and inflammation via 5-HT2A receptor activation and preventing the development of, and inflammation associat...
T36043	17(R)-Protectin D1	17(R)-Protectin D1
	17(R)-Protectin D1 is an aspirin-triggered epimer of the specialized pro-resolving mediator protectin D1 .1It decreases leukotriene B4-induced transendothelial migration of human polymorphonuclear (PMN) neutrophils when ...
T3775	Armepavine	R-Armepavine,(-)-Armepavine	IκB/IKK , NF-κB
	Armepavine (R-Armepavine) exerted both in vitro and in vivo antifibrotic effects in rats, with inhibition of NF-κB, JunD and C/EBP pathways. It improves experimental autoimmune crescentic glomerulonephritis.		IκB/IKK , NF-κB
T83895	NCI 126224	NSC 126224
	NCI 126224, a toll-like receptor 4 (TLR4) antagonist, demonstrates selective inhibition of nitric oxide (NO) production in RAW 264.7 macrophages, triggered by the TLR4 agonist LPS (IC50 = 0.31 µM), as opposed to minimal ...