tlr8 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T40039	TLR8 agonist 2	TLR8 agonist 2
	TLR8 agonist 2 is a highly effective and specific compound that activates TLR8, possessing an EC 50 of 3 nM in human TLR8. Notably, TLR8 agonist 2 demonstrates lower activity towards human TLR7, with an EC 50 of 33.33 μM...
T7347	CU-CPT-8m	TLR8-specific antagonist	TLR
	CU-CPT-8m (TLR8-specific antagonist) is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM)		TLR
T7302	CU-CPT9b	CU-CPT-9b,TLR8-specific antagonist 1	TLR
	CU-CPT9b (TLR8-specific antagonist 1) is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM). It inhibits activation of NF- B induced by the TLR8 agonist R-848 in TLR8-overexpressing HEK-Blue cells with an IC50 valu...		TLR
T40040	TLR8 agonist 2 hydrochloride
	TLR8 agonist 2 hydrochloride is a highly potent and selective agonist for human TLR8, exhibiting an EC50 of 3 nM. However, its activity towards human TLR7 is considerably weaker, with an EC50 of 33.33 μM.
T63848	TLR8 agonist 4
	TLR8 agonist 4 was effective in inhibiting both wild-type and drug-resistant (lamivudine and entecavir) HBV strains with their IC50 values of 0.15 and 0.10 μM, respectively.
T72830	TLR8 agonist 5
	TLR8 Agonist 5, exhibiting potent efficacy as a TLR8 agonist, demonstrates an EC50 of 20 nM in HEK-Blue hTLR8, effectively activating the immune response.
T79151	TLR8 agonist 6
	Compound A, a potent TLR8 agonist, exhibits an EC50 of 0.052 µM and promotes the production of IL-12p40 in human PBMCs with an EC50 of 0.031 µM. This compound is applicable for research in virus resistance, infection res...
T38423	CL097	CL097	Reactive Oxygen Species , TLR
	CL097 is an effective agonist of TLR7 and TLR8. CL097 induces pro-inflammatory cytokines in macrophages and NADPH oxidase priming, thereby increasing the fMLF-stimulated ROS production.		Reactive Oxygen Species , TLR
T7317	CU-CPT-9a		TLR
	CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells-		TLR
T35349	CU-CPD107	CU-CPD107	TLR
	CU-CPD107 is a selective agonist of toll-like receptor 8 (TLR8) and also shows activation activity against ssRNA ligands. CU-CPD107 acts as an inhibitor of TLR8 signaling in the presence of R848 (IC50=13.7 μM). CU-CPD10...		TLR
T9645	CU-115	N-(4-(3,5-bis(trifluoromethyl)phenoxy)phenyl)-2-fluoro-6-iodobenzamide	TLR
	CU-115 is a selective and potent TLR8 antagonist with IC50 of 1.04 µM and =>50 µM for TLR8 and TLR7, respectively. CU-115 decreases production of TNF-α and IL-1β activated by R-848 in THP-1 cells.		TLR
T10899	CU-CPT17e		TLR
	CU-CPT17e is a potent agonist of TLR(TLR3, TLR8, and TLR9).		TLR
T13167	TLR7/8 agonist 3		TLR
	TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.		TLR
T9570	Enpatoran		TLR
	Enpatoran is an inhibitor of TLR7(IC50 = 11.1 nM) and TLR8(IC50 = 24.1 nM). Enpatoran was found to be inactive against TLR3, TLR4, and TLR9 in vitro and in vivo.		TLR
T27034	CL075	3M002,CL-075	NF-κB , TLR , MyD88
	CL075 (3M002) is a selective TLR8 agonist.CL075 has immunomodulatory activity by triggering the MyD88-dependent signaling pathway, activating NF-κB and IRF7 to elicit the production of inflammatory cytokines and type I i...		NF-κB , TLR , MyD88
T38078	TLR7/8-IN-1	TLR7/8-IN-1	TLR
	TLR7/8-IN-1, a crystalline TLR7/TLR8 inhibitor, is a valuable compound for autoimmune disease research[1].		TLR
T72253	AXC-715 trihydrochloride	T785 trihydrochloride	TLR
	AXC-715 trihydrochloride (T785 trihydrochloride) is a TLR7/TLR8 dual agonist for the synthesis of antibody-adjuvanted immunocouplings. The couplings are mostly programmed death ligand 1 (PD-L1) attached to one or more an...		TLR
T6898	Motolimod	VTX-378,VTX-2337	TLR
	Motolimod (VTX-378) (VTX-2337) is an effective and specific Toll-like receptor (TLR) 8 agonist (EC50: 100 nM), > 50-fold selectivity over TLR7.		TLR
T60052	BMS-905		TLR
	BMS-905 is a potent dual inhibitors of TLR7 and TLR8 with good selectivity against TLR9 and other family members. BMS-905 can be used in studies about the treatment of diseases such as psoriasis, arthritis, and lupus.		TLR
T5561	TLR7/8 agonist 1 dihydrochloride	TLR7/8 agonist-5d	TLR
	TLR7/8 agonist 1 dihydrochloride (TLR7/8 agonist-5d) is a TLR7/8 agonist which shows prominent immunostimulatory activities.		TLR