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CL075

Catalog No. T27034 CAS 256922-53-9

Synonyms: 3M002, CL-075

CL075 (3M002) is a selective TLR8 agonist.CL075 has immunomodulatory activity by triggering the MyD88-dependent signaling pathway, activating NF-κB and IRF7 to elicit the production of inflammatory cytokines and type I interferon (IFN).

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CL075, CAS 256922-53-9

Pack Size	Availability	Price/USD	Quantity
2 mg	In stock	$ 58.00
1 mL * 10 mM (in DMSO)	In stock	$ 98.00

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Purity: 99.25%

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Description	CL075 (3M002) is a selective TLR8 agonist.CL075 has immunomodulatory activity by triggering the MyD88-dependent signaling pathway, activating NF-κB and IRF7 to elicit the production of inflammatory cytokines and type I interferon (IFN).
In vitro	CL075 (2 μM; 4 h) induces the production of IL-6, IL-8 and IFN-γ in rabbit splenocytes.[1] CL075 (2 μM; 48 h) induces total IgM production and cell proliferation in rabbit splenocytes.[1] CL075 (2 μM; 7 h) activates rabTLR8 in 293 cells.[1]
In vivo	CL075 (5 μM; s.c.) activates mild antigen-specific antibody responses in rabbits.[1]

Synonyms	3M002, CL-075
Molecular Weight	243.33
Formula	C13H13N3S
CAS No.	256922-53-9

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 19.8 mg/mL (81.4 mM ), Sonication and heating are recommended.

References and Literature

1. Lai CY, et al. TLR7/8 agonists activate a mild immune response in rabbits through TLR8 but not TLR7. Vaccine. 2014;32(43):5593-5599. 2. Spranger S, et al. Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075. J Immunol. 2010;185(1):738-747. 3. Makni-Maalej K, et al. TLR8, but not TLR7, induces the priming of the NADPH oxidase activation in human neutrophils. J Leukoc Biol. 2015;97(6):1081-1087. 4. Yang H, et al. Expression of TLR8 in human cervical cancer HeLa cells and the effect of TLR8 agonist on the cell proliferation and apoptosis. Zhonghua Zhong Liu Za Zhi. 2011;33(9):643-648.

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Keywords

CL075 256922-53-9 Immunology/Inflammation NF-Κb TLR MyD88 NF-κB 3M-002 3M002 3M 002 CL 075 CL-075 inhibitor inhibit

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