Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Motolimod (VTX-378) (VTX-2337) is an effective and specific Toll-like receptor (TLR) 8 agonist (EC50: 100 nM), < 50-fold selectivity over TLR7.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 51.00 | |
2 mg | In stock | $ 73.00 | |
5 mg | In stock | $ 122.00 | |
10 mg | In stock | $ 197.00 | |
25 mg | In stock | $ 396.00 | |
50 mg | In stock | $ 592.00 | |
100 mg | In stock | $ 845.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 135.00 |
Description | Motolimod (VTX-378) (VTX-2337) is an effective and specific Toll-like receptor (TLR) 8 agonist (EC50: 100 nM), > 50-fold selectivity over TLR7. |
Targets&IC50 | TLR8:100 nM(EC50) |
In vitro | VTX-2337 induces the production of both TNFα (EC50: 140 nM) and IL-12 (EC50: 120 nM) in PBMCs. In mDCs and monocytes, VTX-2337 specifically induces the production of IL-12 and TNFα via NF-κB activation. VTX-2337 also induces IFNγ production from NK cells, enhances the lytic function of NK cells and augments ADCC. |
In vivo | In ovarian cancer mouse model, TX-2337 augments the effect of pegylated liposomal doxorubicin (PLD). |
Kinase Assay | The activity of specific TLR agonists is assessed using the secretory embryonic alkaline phosphatase (SEAP) reporter gene that is linked to NF-κB activation in response to TLR stimulation. Measurement of SEAP activity using the Quanti-blue substrate (InvivoGen) after TLR agonist treatment is carried out. |
Cell Research | PBMCs or purified NK cells are prepared as previously described, and the purity of NK cells was approximately 99%. NK cell-mediated cytotoxicity is assessed by Calcein-AM release from labeled target cells. In brief, PBMCs or purified NK cells are cultured for 48 hours in RPMI medium in the presence of VTX-2337 (167 or 500 nmol/L) before incubation with target cells. |
Synonyms | VTX-378, VTX-2337 |
Molecular Weight | 458.6 |
Formula | C28H34N4O2 |
CAS No. | 926927-61-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 12 mg/mL (26.2 mM)
DMSO: 51 mg/mL (111.2 mM)
You can also refer to dose conversion for different animals. More
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Motolimod 926927-61-9 Immunology/Inflammation TLR inhibit VTX-378 VTX378 VTX 2337 VTX2337 Inhibitor Toll-like Receptor (TLR) VTX-2337 VTX 378 inhibitor