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Search Result

Search Results for " tgfβri "

19

Compounds

Cat No. Product Name Synonyms Targets
T9523 TGFβRI-IN-3 TGF-beta/Smad
TGFβRI-IN-3 inhibits TGFβR1 with an IC 50 of 0.79 nM with 2000-fold selectivity against MAP4K4. TGFβRI-IN-3 is a highly selective TGFβR1 inhibitor that has potential applications in immuno-oncology [1].
T13137 TGFβRI-IN-1 TGF-beta/Smad
TGFβRI-IN-1 is an oral active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase(IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII, respectively ).
T62559 TGFβRI-IN-4
TGFβRI-IN-4 is a potent, orally active TGFβ receptor type I kinase (TGFβRI) inhibitor that acts on ALK5 (IC50: 44 nM) and NIH3T3 (IC50: 42.5 nM).TGFβRI-IN-4 inhibits tumor growth and tumor weight in a xenograft tumor mod...
T72976 TGFβRI-IN-6
TGFβRI-IN-6 is a potent TGFβRI inhibitor with an IC50 value of 0.55 nM.TGFβRI-IN-6 has the potential to enhance anti-tumour immunity.
T60931 TGFβRI-IN-5
TGFβRI-IN-5 (Compound 4b) is a potent TGFβRI inhibitor with an IC50 of 0.08 μM. TGFβRI-IN-5 shows amazing anticancer activity against all the tested cell lines which enhances apoptosis and arrested G2/M phase of cell cyc...
T13139 TP-008 TGFβRI-IN-2 Others
TGFβRI-IN-2 is a selective, potent and orally active inhibitor of (Activin-Like Kinase 5) ALK 5(pIC50 and pEC50 values of 7.6 and 6.63, respectively).
T5125 LY3200882 TGF-beta/Smad
LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).
T12433 PF-06952229 PF06952229 TGF-beta/Smad
PF-06952229 is a selective inhibitor of TGFβRI. PF-06952229 can be used in studies about the treatment of solid tumors, specifically metastatic breast cancer.
T2510 Galunisertib LY2157299 TGF-beta/Smad
Galunisertib (LY2157299) is an orally available inhibitor of TGFβRI kinase (IC50: 56 nM) with potential antineoplastic activity.
T9837 N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-bromoaniline ALK
Compound 12d is a potent ALK5 inhibitor with an IC50 of 7nM.
T2109 SD-208 ALK5 Inhibitor V,SD208 TGF-beta/Smad
SD-208 (ALK5 Inhibitor V), a selective TGF-βRI (ALK5) inhibitor (IC50: 48 nM), is >100-fold selectivity over TGF-βRII.
T6337 RepSox ALK5 Inhibitor II,SJN 2511,E-616452 ALK , TGF-beta/Smad
RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM). RepSox induces adipogenesis in MEFs cells.
T61203 ALK5-IN-8
ALK5-IN-8 is a highly effective inhibitor of TGFβRI (ALK5). It hinders the phosphorylation of ALK5 on downstream signaling proteins (Smad2 or Smad3) by obstructing the interaction between TGFβRI and ligands. Consequently...
T64051 ALK5-IN-9
ALK5-IN-9 is a potent, orally active inhibitor of TGFβRI (ALK5). ALK5-IN-9 inhibits ALK5 autophosphorylation (IC50: 25 nM) and inhibits NIH3T3 cell activity (IC50: 74.6 nM). ALK5-IN-9 has shown research potential in canc...
T2048 LY-364947 LY 364947,HTS466284 MLK , Casein Kinase , TGF-beta/Smad , RIP kinase
LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I.
T35896 AZ 12799734 AZ12799734 ALK
AZ 12799734 is an orally active, selective and potent dual inhibitor of TGFBR1 and ALK5 with inhibitory effects on BMP and TGFβ for the study of tumours.
T10426 AZ12601011 ALK
AZ12601011 is a highly potent and selective inhibitor of the TGFBR1 kinase, administered orally. It displays an IC50 of 18 nM and a Kd of 2.9 nM. By selectively targeting ALK4, TGFBR1, and ALK7, AZ12601011 effectively in...
T21295 BIX02189 BIX 02189 ERK , MEK
BIX02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM).
T1744 BIX02188 Apoptosis , MEK
BIX02188 is a selective and potent MEK5 inhibitor that inhibits MEK5-induced apoptosis in cells expressing the oncogenic mutant FLT3-ITD.
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